Effects of Testosterone Replacement Therapy on Skin, Hair, and Appendages

The document discussed the effects of testosterone replacement therapy on the skin, hair, and appendages in men with hypogonadism. It was noted that hypogonadism led to dermatological changes such as thinner skin, increased wrinkling, and reduced body hair, without the typical male pattern baldness. Prepubertal hypogonadism resulted in sebostase due to lack of sebaceous gland stimulation and a lack of increased pigmentation in genital skin. While reactions to oral or intramuscular androgens were rare, non-scrotal transdermal testosterone therapies more frequently caused irritative or allergic skin changes.