Single Injection of Very Mild Dose Botox in the Vastus Lateralis Improves Testicular Spermatogenesis and Sperm Motility in Aging Experimental Mice

    October 2021 in “ bioRxiv (Cold Spring Harbor Laboratory) ”
    Risna Kanjirassery Radhakrishnan, Sowbarnika Ravichandran, Aishwarya Sukesh, Balamuthu Kadalmani, Mahesh Kandasamy
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    Studysummary This study found that a mild intramuscular dose of BOTOX increased spermatogenesis and improved sperm quality in ageing mice, suggesting potential benefits for managing male infertility.
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    The study investigated the effects of a single, mild dose of BOTOX injected into the vastus lateralis muscle on testicular function in ageing mice. The results showed that a dose of 1 U/kg bodyweight improved spermatogenesis and increased sperm count and motility. This was associated with enhanced activity of key antioxidants in the testis. The findings suggested that a mild intramuscular dose of BOTOX could be a potential treatment strategy for managing and preventing male infertility.
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