Essential Fatty Acid Deficiency and Its Effects Upon Reproductive Organs of Male Rabbits

June 1967 in “ The journal of nutrition/The Journal of nutrition ”

Balwant Ahluwalia, Gregory Pincus, Ralph T. Holman

essential fatty acid deficiency 5,8,11-eicosatrienoic acid linoleate family fatty acids hair loss androgen secretion anterior pituitary gland anterior hypophyseal function gonadal degeneration

TLDR Lack of essential fatty acids in diet causes reproductive issues and poor health in male rabbits.

The study investigated the effects of essential fatty acid (EFA) deficiency on five immature male New Zealand rabbits over 14 weeks. The deficiency led to significant changes in the fatty acid composition of the testes, including an increase in 5,8,11-eicosatrienoic acid and a decrease in linoleate family fatty acids. Rabbits exhibited diminished growth, feed efficiency, and hair loss. Testes showed extensive degenerative changes, with no stages beyond secondary spermatocyte evident. Male accessory gland weights were reduced, indicating lower androgen secretion. Histological examination revealed degenerative changes in the anterior pituitary gland, suggesting impaired anterior hypophyseal function as a primary cause of gonadal degeneration.

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