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This study found that finasteride and minoxidil act as hormone disruptors in mice, with finasteride having a more significant association with reproductive injuries, such as damage to the epididymis and reduced semen volume.

In this study, flutamide at therapeutic doses caused significant histological changes in the testes and epididymis of adult albino rats, reducing androgen receptor immunoreactivity and increasing estrogen receptor immunoreactivity.

This study found that finasteride decreased plasma dihydrotestosterone levels and altered steroid metabolism, similar to the profile of male pseudohermaphrodites with inherited 5a-reductase deficiency.

Testosterone boosts fluid and electrolyte secretion in seminal vesicles, aiding sperm function.

This study suggests that 5α-reductase inhibitors do not significantly affect male reproductive function but may require caution in men with oligospermia or ejaculatory issues.

A 19-year-old male with delayed puberty was successfully treated for a condition that prevents normal hormone production.

This study found that finasteride treatment of male rats led to changes in their male offspring's testicular gene expression, potentially affecting sperm function in response to odorant-like signals.

This study found that finasteride treatment in male rats may lead to changes in connexin 43 expression in the testes of their offspring, potentially affecting spermatogenesis.

This study found that finasteride significantly reduced prostate weight and DHT levels in male mastomys, but not in females, suggesting unique androgen metabolism in female prostates.

This study found that among men with Benign Prostatic Hyperplasia, treatment with the 5α-reductase inhibitor finasteride for three months significantly reduced levels of dihydrotestosterone and estradiol, hormones involved in prostate enlargement, without altering follicle-stimulating hormone or luteinizing hormone levels.

The researchers reported that finasteride treatment in male rats may lead to changes in antioxidant enzyme activity in their offspring's epididymis, potentially affecting sperm maturation.

This study reported that prenatal exposure to dihydrotestosterone altered long-term androgen metabolism in juvenile male rats, suggesting different regulatory mechanisms for 5a-reductase in hypothalamic versus pituitary tissues.

This study found that zinc deficiency in goats led to lower plasma zinc levels, decreased growth rate, smaller testicles, reduced libido, and was associated with higher mortality compared to control goats.

Young and adult hamsters both respond similarly to testosterone and finasteride treatments, but young hamsters aren't good for testing the inhibitory activity of a specific enzyme.

The journal retracted an article due to inaccurate statistics and asked the authors to revise and resubmit it.

This review discusses the structure and function of the testes in male reproduction and development, noting the complex hormonal regulation within the hypothalamic-pituitary-gonadal axis but reports no new clinical results.

In this cohort study of young Danish men, self-reported older age at voice break was linked to certain reproductive hormone changes that suggest reduced male fecundity, but associations with semen characteristics and testicular volume were not statistically significant.

This study on rats found that adrenalectomy was associated with increased hair loss compared to sham adrenalectomy, where one adrenal was left intact.

This article reviews the impact of aging and related urologic conditions on male fertility, highlighting the effects of various treatments on sperm parameters and recommending pre-treatment counseling for fertility preservation. It reports no new clinical results.

This case report describes a middle-aged man with a growing scrotal mass, diagnosed as a benign proliferating trichilemmal tumor, which can mimic squamous cell carcinoma, highlighting the importance of correct diagnosis.

Long-term use of finasteride and minoxidil may harm male reproductive health in mice.

Dutasteride and finasteride can change semen and hormone levels in men.

This study found that prolonged use of finasteride and dutasteride in young men with androgenic alopecia is linked to a decline in semen quality over time, particularly affecting sperm motility and DNA integrity, with dutasteride showing a slightly greater impact than finasteride.

In this case report, a patient with pseudovaginal perineoscrotal hypospadias due to 5α-reductase deficiency presented gender dysphoria, and after genomic sequencing confirmation, injectable testosterone undecanoate treatment successfully developed desired male secondary sexual characteristics.

In this study, testosterone increased the expression of epithelial sodium channel proteins and mRNAs in rat kidneys, suggesting a potential mechanism for its effect on blood pressure through enhanced sodium reabsorption.

The testes significantly contribute to vitamin D metabolism and may affect male reproductive health and conditions like hair loss.

In this study, testosterone was reported to increase aquaporin levels and water reabsorption in the kidneys of male rats, potentially leading to higher blood pressure, with effects mitigated by flutamide and finasteride.

Finasteride may cause breast enlargement, low testosterone a risk factor.

This study reviewed human evidence on the effects of 5α-reductase inhibitors, finasteride and dutasteride, on semen parameters and gonadotrophins, finding finasteride causes mild, reversible changes, while dutasteride may lead to more pronounced and potentially less reversible impacts, suggesting caution for those planning to conceive.