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Spironolactone may make some cancer treatments more effective by blocking a protein that helps cancer cells survive.

A complex X chromosome rearrangement can increase the risk of multiple autoimmune diseases.

Common variants in the Trichohyalin gene are linked to straight hair in Europeans.

Stopping mitochondrial respiration can prevent brain cancer spread in skin cancer patients, and plant compound β-sitosterol could help achieve this.

Breast cancer treatments work better with AR activation, improving results and reducing side effects.

Forensic DNA phenotyping can help generate new leads in cold cases but faces accuracy, legal, and acceptance challenges.

Rare ULBP3 gene changes may raise the risk of Alopecia areata, a certain FAS gene deletion could cause a dysfunctional protein in an immune disorder, and having one copy of a specific genetic deletion is okay, but two copies cause sickle cell disease.

Current treatments for Alopecia Areata have mixed success, and there's a need for better, more accessible options and support for affected individuals.

The guidelines suggest using various treatments, including antidepressants and steroids, for alopecia areata and discuss the condition's genetic and immune aspects.

A five-month-old boy with Omenn syndrome successfully recovered after a stem cell transplant with reduced intensity conditioning.

Changes in testosterone and estrogen receptor genes can affect how men age, influencing body fat, hair patterns, and possibly leading to skin disorders.

Certain genetic variants in the androgen receptor are linked to higher PSA levels, potentially affecting prostate cancer screening outcomes.

Certain genes and X chromosome patterns may significantly contribute to the development of hair loss.

Kennedy's disease leads to muscle weakness and sensory issues, has no cure but manageable symptoms, and future treatments look promising.

The conclusion is that adult males with muscle weakness and hormonal imbalances should be tested for Kennedy's disease.

Insulin resistance and obesity are key factors in the development and worsening of polycystic ovary syndrome, and lifestyle changes are important for managing it.

Signaling pathways are crucial for hair growth in goats.

Certain gene patterns in breast cancer are linked to how active hormone receptors are and could affect patient survival.

The vitamin D receptor is crucial for bone health and affects various body systems, with mutations potentially leading to disease.

Exposure to too much androgen before birth might cause polycystic ovary syndrome later in life.

PCOS is caused by both genetics and environmental factors like diet and obesity.

Genetics and hormones play a role in male and female hair loss, but more research is needed to fully understand it.

Certain gene variants may contribute to high androgen levels in women with polycystic ovary syndrome.

The document concludes that more research is needed to understand excessive hair growth in women with normal hormone levels and regular ovulation.

Genetics play a role in acne, but how exactly they contribute is not fully understood.

New treatments for PCOS focus on insulin resistance and reducing testosterone levels, along with traditional hormone therapies.

WNT10A mutations cause varied symptoms in patients with odonto-onycho-dermal dysplasia.

High levels of male hormones are very common in women with PCOS and affect their metabolism differently depending on their weight.

Metformin helps regulate menstrual cycles, induce ovulation, and improve pregnancy outcomes in women with PCOS.

Longer CAG and GGN repeats increase alopecia risk, but no significant link to post-finasteride syndrome found.