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Higher DHT levels are linked to worse heart changes in severe aortic valve stenosis patients.

Higher testosterone harms sperm motility, while higher estradiol improves sperm survival.

Finasteride helps regrow hair and shrink prostate by reducing DHT, with some sexual side effects.

Minoxidil given intravenously caused small changes in diastolic blood pressure and increased heart rate at higher concentrations in patients with high blood pressure.

The model suggests that scalp tension could lead to hair loss, with factors like blood vessel hardening, enlarged oil glands, and poor microcirculation also playing a role. It also hints at a possible link between skull shape and baldness pattern.

The paper suggests that hair loss might be caused by skull growth, not just DHT's effect on hair follicles, and calls for more research.

Most hirsutism cases are due to PCOS, and treatment focuses on lowering testosterone and blocking its effects.

Blocking the enzyme 5α-reductase can shrink the prostate and help treat enlarged prostate issues.

Overweight women with PCOS have higher levels of certain hormones that could indicate a higher risk of heart and metabolic problems.

Dosing time affects finasteride's effectiveness and safety in rats.

Testosterone undecanoate safely and effectively increased penis size in male children with 5-alpha-reductase deficiency.

Higher BMI and lower testosterone are linked to more aggressive prostate cancer.

Inflammation may be linked to hair loss, and targeting specific enzymes could help treat it.

Finasteride is a safe, effective treatment for hirsutism with fewer side effects.

Dihydrotestosterone treatment can help penis growth in boys with 5α-reductase deficiency but doesn't fully normalize size after puberty.

Finasteride and dutasteride may help prevent hair loss but could cause side effects like sexual dysfunction and psychological issues.

Finasteride effectively treats male pattern baldness, improving hair growth and density.

Finasteride increases hair density in female androgenetic alopecia, but individual results may vary.

The document explains hair biology, the causes of hair loss, and reviews various hair loss treatments.

Finasteride doesn't affect bone density in male rats.

New treatments for hair loss show promise, especially finasteride for men and a stronger minoxidil formula.

Hormones and genetics play key roles in male and female baldness, which can affect mental health and may be linked to other health issues.

Over 50% of women over 50 experience hair loss, with minoxidil being the only proven effective treatment.

Hormonal treatments can help with hair loss, acne, and excess hair growth, but it takes 3-6 months to see results and patients should know the possible side effects.

Treat hair loss in postmenopausal women with diet, avoiding certain drugs, and using medications like minoxidil or finasteride.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Finasteride treats enlarged prostate and baldness, but may cause limited urinary improvement and sex-related side effects.

Finasteride effectively treats hirsutism in women, but more research needed for long-term results.

Suppressing certain hormones might help prevent prostate cancer.

Finasteride helps induce ovulation in nonresponder PCOS women.