Finasteride And Dutasteride In The Treatment Of Androgenetic Alopecia: Risk Or Benefit?

May 2024 in “ Brazilian Journal of Hair Health ”

Eduardo Rosa Lucca, Patrícia Stadler Rosa Lucca

finasteride dutasteride androgenetic alopecia 5-alpha-reductase DHT testosterone sexual dysfunction psychological disorders Propecia Avodart

TLDR Finasteride and dutasteride may help prevent hair loss but could cause side effects like sexual dysfunction and psychological issues.

Finasteride and dutasteride are commonly used treatments for androgenetic alopecia, which is influenced by genetic and environmental factors and characterized by an excessive response to androgens. These medications work by inhibiting the enzyme 5-alpha-reductase, which converts testosterone into DHT, thereby preventing the progression of hair loss. However, there is concern about potential side effects, including sexual dysfunction and psychological disorders, in some users. The scientific community is currently debating whether the benefits of using these 5-alpha-reductase inhibitors outweigh the risks, as new treatment methodologies for androgenetic alopecia emerge.

View this study on brazjhairhealth.com →

Discuss this study in the Community →

Related Community Posts Join

6 / 1000+ results

community Study shows further evidence that finasteride and dutasteride take 12-18 months or more to show significant results. Do NOT give up early

in Finasteride/Dutasteride 247 upvotes 1 year ago

The conversation discusses the effectiveness of finasteride and dutasteride in treating hair loss, emphasizing that significant results often take 12-18 months or more. Dutasteride is generally considered superior, with similar or fewer side effects than finasteride, but patience is required for noticeable improvement.

community Diffuse hair loss and scalp biopsies

in Research 692 upvotes 3 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community Is there a topical androgen receptor blocker so we don't have to fuck with the enzyme and destroy our allopregnanolone, but go and hit the end target straight?

in Treatment 46 upvotes 6 months ago

The conversation discusses topical androgen receptor blockers for hair loss, mentioning Clascoterone, Pyrilutamide, GT20029, and RU58841. Ketoconazole's effectiveness and application methods are also debated.

community Saying creatine causes loss on fin/dut makes no sense and this is why

in Finasteride/Dutasteride 42 upvotes 9 months ago

The conversation discusses whether creatine causes hair loss for those using finasteride or dutasteride, with some suggesting creatine might increase DHT or upregulate androgen receptors, potentially leading to hair loss. Others argue the evidence is not conclusive, citing limited studies and personal anecdotes, with some avoiding creatine as a precaution.

community Ultimate DHT/finasteride microdosing graph to replace the commonly one referenced on forums

in Finasteride/Dutasteride 204 upvotes 3 years ago

Hair loss treatments, specifically, discussing the effectiveness and side effects of finasteride, minoxidil, and RU58841 in various microdoses. It also includes an updated graph which provides information on how different doses affect DHT levels, scalp skin and serum androgen levels, as well as hair count.

community Be careful when switching from Finasteride to Dutasteride because for more efficacy.

in Finasteride/Dutasteride 13 upvotes 1 month ago

Switching from finasteride to dutasteride may be more effective for hair regrowth due to dutasteride's stronger enzyme inhibition, but combining both drugs could enhance results. Some users report better outcomes with dutasteride, while others recommend a gradual transition to prevent potential hair loss.

Related Research

5 / 5 results

research The Diagnosis and Treatment of Androgenetic Alopecia: A Review of the Most Current Management

September 2023 in “Forum Dermatologicum”

Various treatments for common hair loss in men and women are effective, but should be tailored to individual needs and potential side effects.

research Evaluation of the Therapeutic Effects of AGA Drugs by Measuring Finasteride, Dutasteride, and Dihydrotestosterone in Hair

June 2023 in “Clinica Chimica Acta”

Finasteride and dutasteride effectively reduce DHT in hair, which may help evaluate their treatment success for hair loss.

Dutasteride for Men with Androgenic Alopecia Unresponsive to Finasteride