research How real is senescent alopecia? A histopathologic approach
In this study, old age was concluded not to be a significant cause of hair loss, with most cases in the elderly appearing to be androgen-driven.
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research Microarray analysis of androgenetic and senescent alopecia: Comparison of gene expression shows two distinct profiles
The conclusion is that androgenetic alopecia and senescent alopecia have unique gene changes, suggesting different causes and potential treatments for these hair loss types.
research Androgenetic, Diffuse and Senescent Alopecia in Men: Practical Evaluation and Management
This review discusses the evaluation and management of male baldness and related conditions, but reports no new clinical results.
research Comparative Gene Expression Profiling of Senescent and Androgenetic Alopecia Using Microarray Analysis
SA linked to mitochondrial issues and oxidative stress, while AGA involves disrupted hair growth genes.
research Oxidative Stress–Associated Senescence in Dermal Papilla Cells of Men with Androgenetic Alopecia
This study suggests that oxidative stress may contribute to androgenetic alopecia by inducing premature senescence and secretion of hair growth inhibitors in dermal papilla cells from balding scalp.
research Rejuvenating senescent hair follicles: a novel conjugated linoleic acid based nanovesicle approach to treat androgenic alopecia
This study found that in androgenetic alopecia mice, MNX@Arg-CLAVs, a novel nanovesicle platform containing minoxidil and conjugated linoleic acid, enhanced hair regeneration and reduced hair follicle aging more effectively and with less irritation compared to traditional minoxidil tincture.
research 453 Signaling by Senescent Melanocytes Induces New Hair Growth and Informs Hair Growth-Activating Injectable for Androgenetic Alopecia
AMP-303 injections can increase hair growth in androgenetic alopecia with minimal side effects.
research Cellular Senescence: Ageing and Androgenetic Alopecia
This review summarizes biological links between aging and androgenetic alopecia, particularly focusing on cellular senescence, and discusses potential therapeutic strategies, but reports no new clinical results.
research Rejuvenating senescent hair follicles: a novel conjugated linoleic acid based nanovesicle approach to treat androgenic alopecia
This study found that MNX@Arg-CLAVs nanovesicles enhanced hair regeneration and reduced aging in hair follicles in AGA mice, with less skin irritation compared to traditional minoxidil tincture.
research Rejuvenating senescent hair follicles: a novel conjugated linoleic acid based nanovesicle approach to treat androgenic alopecia
In this study on mice, researchers developed CLA-loaded nanovesicles that showed potential anti-aging effects on hair follicles and enhanced hair growth compared to commercial minoxidil, with lower skin irritation, suggesting a promising approach for treating androgenetic alopecia.
research ACOD1 deficiency promotes DDX1 methylation–mediated mitochondrial dysfunction and dermal papilla cell senescence in androgenetic alopecia
This study found that ACOD1 deficiency in dermal papilla cells promotes mitochondrial dysfunction and contributes to cellular senescence in androgenetic alopecia, suggesting ACOD1 as a potential therapeutic target and 4-octyl itaconate as a promising treatment option for AGA.
research Oxidative Stress and Hormone-regulated Dermal Papilla Cell-targeted Nanomodulators: Reverse Cellular Senescence for Androgenetic Alopecia Therapy
This study presents a novel drug delivery system combining finasteride and cerium oxide nanoparticles, which successfully reversed cellular senescence and promoted hair regeneration in androgenetic alopecia mouse models, showing efficacy comparable to, and sometimes better than, minoxidil.
research Role of UVA-driven cellular senescence via mTOR activation in dihydrotestosterone-induced hair loss in androgenetic alopecia mouse model
UVA exposure worsens hair loss by activating a specific cell pathway.
research Androgenic Alopecia and Stress-Induced Premature Senescence by Cumulative Ultraviolet Light Exposure
In this study, researchers reported that chronic UV exposure may contribute to androgenic alopecia progression by influencing hair cycle changes and exacerbating solar elastosis in the scalp.
research Comparative Histopathology of Androgenetic Alopecia, Diffuse Alopecia, and Senescent Alopecia
research Ultraviolet Light-Induced Leukoderma of the Scalp Associated with Androgenetic Alopecia: Senescent Actinic Depigmentation of the Scalp
This study reports cases of androgenetic alopecia patients with depigmented macules on sun-exposed scalp areas, suggesting potential ultraviolet-induced scalp leukoderma not covered in existing dermatology texts.
research Additional file 1 of Rejuvenating senescent hair follicles: a novel conjugated linoleic acid based nanovesicle approach to treat androgenic alopecia
research Additional file 1 of Rejuvenating senescent hair follicles: a novel conjugated linoleic acid based nanovesicle approach to treat androgenic alopecia
research Oleanolic acid alleviates stress-induced alopecia via modulating brain-skin axis: Neuroprotection and dermal papilla cell senescence
research Histopathology of non-scarring alopecia
The document describes how to tell different types of non-scarring hair loss apart by looking at hair and scalp tissue under a microscope.
research Age-related hair changes in men: Mechanisms and management of alopecia and graying
This review discusses the mechanisms and treatment strategies for age-related hair changes, such as androgenetic alopecia and hair graying, and reports no new clinical results.
research Camellia japonica seed extract promotes hair growth by preventing dermal papilla cell senescence and activating hair follicle stem cells
This study found that Camellia japonica seed extract promotes hair growth by preventing premature cellular senescence and enhancing the activity of hair follicle stem cells in cases of pattern hair loss.
research LncRNA H19 inhibited dermal papilla cell senescence process through miR-29a by targeting Wnt/β-catenin signaling pathway
This research observed that overexpression of lncRNA H19 in human dermal papilla cells inhibited cell senescence and maintained hair follicle-inducing abilities by activating the Wnt signaling pathway, suggesting potential therapeutic strategies for androgenetic alopecia.
research Secreted Frizzled‐Related Protein 2 ( SFRP2 ) Induces Follistatin‐Like 1 ( FSTL1 ) to Regulate Dihydrotestosterone ( DHT )‐Induced Dermal Papilla Cell Mitochondrial Dysfunction and Senescence
This study found that knocking down SFRP2 in an AGA model improved hair regeneration and reduced cellular dysfunction, suggesting that targeting the SFRP2-FSTL1 axis could be a promising therapeutic strategy for androgenetic alopecia.
research Screening Potential Drugs From Nitric Oxide Donors for Treating Alopecia Based on Network Pharmacology and Experimental Validation
This study suggests that hesperidin may regulate pathways in hair follicle cells to help mitigate hair loss, revealing molecular mechanisms of nitric oxide donor-mediated hair follicle protection.
research Premature Senescence of Balding Dermal Papilla Cells In Vitro Is Associated with p16INK4a Expression
This study found that balding dermal papilla cells show premature senescence and altered expression of stress and DNA damage markers, suggesting sensitivity to environmental stress in androgenetic alopecia.
research Androgen Receptor Accelerates Premature Senescence of Human Dermal Papilla Cells in Association with DNA Damage
This study found that androgen/androgen receptor signaling accelerates premature senescence in dermal papilla cells, highlighting a potential target for treating androgenetic alopecia.
research Single‐cell transcriptomics reveals a senescence‐associated IL ‐6/ CCR6 axis driving radiodermatitis
This study found that targeting IL-6, IL-1, and CCR6 signaling pathways may effectively reduce irradiation-induced alopecia and dermatitis in radiotherapy patients.
research Cellular Senescence and Aging in Myotonic Dystrophy
This review discusses the similarities between myotonic dystrophy and aging, highlighting the role of cellular senescence in its pathophysiology, and reports no new clinical findings; the authors note potential anti-aging therapy applications.
research Alopecia Androgenética Feminina em Paciente Idosa: Relato de Caso com Protocolo Regenerativo Integrativo e Modulação de Senescência
In this preprint, an integrative regenerative protocol involving microneedling, plant-derived exosomes, and other therapies was used to treat androgenetic alopecia in an elderly woman, resulting in improved hair density and scalp coverage.