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We need to learn more about 5α-reductases and neuroactive steroids to safely make drugs targeting these enzymes.

Acne can't be cured but can be managed with treatments like benzoyl peroxide and diet changes; it's costly and can lead to scarring and mental health issues.

A patient with a rare disease had a unique genetic mutation linked to their symptoms.

Hormones during puberty increase certain receptors in the brain, and this change is influenced by estrogen levels.

Inward rectifier potassium channels are important in many body functions and diseases, and could be potential drug targets.

Vitamin D levels in hair don't match those in blood, so hair isn't a reliable indicator of Vitamin D status.

Hydroxychloroquine and chloroquine are not recommended for COVID-19 treatment due to insufficient evidence and safety concerns.

Old psychiatric drugs are increasingly being used for new purposes, and technologies like SmartCube® help create new drugs.

Cirrhosis affects quality of life with various symptoms, requiring a holistic, multidisciplinary approach for management.

Bicalutamide may help treat female pattern hair loss.

Men and women react differently to opioids, with hormones potentially influencing these differences.

Enzymes called 5α-reductases have many body functions and need more research to safely use inhibitors.

Trilostane may help delay epilepsy development by increasing certain brain chemicals.

Switching to extended-release divalproex sodium improved patient-reported tremor but did not change seizure frequency or most side effects.

Sodium metabisulfite increases sodium channel activity, leading to higher cell excitability and potential damage.

Biotin and biotinidase are essential to prevent health issues, and deficiencies require lifelong supplementation.

An 11-month-old boy with Menkes disease had severe brain shrinkage and abnormal blood vessels, and didn't respond well to treatment.

Androgen receptors in the mouse brain may explain cognitive and mood changes in prostate cancer treatment.

Valproic acid and carbamazepine do not change biotin or biotinidase levels but may lower zinc levels, still within normal range.

High mTORC1 activity slows hair growth and causes it to lose color.

Early surgery reduces seizure risk in drug-resistant epilepsy; testosterone to DHT conversion doesn't affect muscle anabolism; veterans with PTSD likely to have riskier opioid use; bevacizumab helps in hereditary bleeding disorder.

Long-term use of seizure medications can disrupt calcium metabolism, but this can be treated with vitamin D or UV light and does not affect seizure control.

Allopregnanolone increases growth and changes gene activity in human brain cancer cells.

Methylated flavonoids may effectively reduce depression and inflammation caused by finasteride.

Anifrolumab treatment improves quality of life and reduces disease activity and steroid use in SLE patients.

Changing neuroactive steroid levels early in life can affect how adult rats respond to alcohol's stimulating effects.

Scientists in India found a safer and efficient way to make a type of medicine called hydantoins from carbamates, which also worked well in making the seizure medicine, Ethotoin.

Low serum complement levels in SLE patients don't always match with disease flares; monitoring C3 and C4 is useful, but cell-bound complement products might better indicate disease activity.

Finasteride may protect brain and improve behavior in rats with liver failure.