77 citations
,
August 2025 in “Signal Transduction and Targeted Therapy” This review highlights the potential of extracellular vesicle-based therapies for treating various diseases, but it also notes challenges like the lack of regulatory guidelines that hinder their clinical development.
45 citations
,
November 2017 in “Biomaterials” This study demonstrated a method for large-scale preparation of self-sorted hair follicle germs in vitro, which successfully generated hair follicles when transplanted into the skin of nude mice.
28 citations
,
December 2012 in “The American Journal of Cosmetic Surgery” This study reported that treatments using ADSC-CM improved hair growth in all participants, with the most pronounced results after four sessions within three to four months.
26 citations
,
August 2016 in “ACS Applied Materials & Interfaces” In this study, cell membrane remodeling with a thermoresponsive boronic acid copolymer was shown to rapidly form spheroids from cancer or cardiac cell lines under standard conditions, promising advances in tissue engineering.
24 citations
,
June 2018 in “Expert Review of Pharmacoeconomics & Outcomes Research” This review discusses the potential of microneedle arrays for drug delivery and in the cosmetic market, but reports no new clinical results; factors for commercial therapeutic use are explored.
23 citations
,
January 2022 in “Biomaterials Science” Non-viral vectors show promise for safe and effective CRISPR/Cas9 gene editing in treating diseases.
19 citations
,
October 2024 in “BMC Medical Informatics and Decision Making” This study used machine learning models to analyze PCOS symptoms for early diagnosis, finding Support Vector Machine and VGG16 algorithms achieved high accuracy rates of 94.44% and 98.29% respectively.
19 citations
,
April 2024 in “Journal of Umm Al-Qura University for Applied Sciences” This review explores the diverse roles of rosemary, covering its nutritional and medicinal uses, cosmetic and pharmaceutical applications, and evaluates various extraction methods, with a focus on sustainable practices and commercial prospects.
18 citations
,
February 2025 in “Drug Delivery and Translational Research” This study demonstrated that a new topical treatment using ketotifen-loaded microneedles, designed for prolonged release, significantly reduced inflammatory markers in an animal model of allergic conjunctivitis, suggesting enhanced therapeutic delivery and sustained ocular benefits.
17 citations
,
June 2021 in “Molecules” This review summarizes the promising role of melatonin combined with nanosized carriers in drug delivery, suggesting enhanced effectiveness in treating various diseases compared to free melatonin.
16 citations
,
July 2020 in “Advanced functional materials” This review discusses the development and application of cell-derived matrices in regenerative medicine and disease modeling, presenting various fabrication techniques and future perspectives, but reports no new results.
15 citations
,
May 2021 in “British journal of dermatology/British journal of dermatology, Supplement” In this review, the authors discuss the potential for cell therapy, such as hematopoietic stem cell transplantation and mesenchymal stromal cells, to treat severe psoriasis unresponsive to biological therapies, while highlighting the associated risks, costs, and regulatory challenges.
15 citations
,
December 2016 in “Advanced Pharmaceutical Bulletin” This study found that N-acetyl-glucosamine-loaded nanostructured lipid carriers showed promise for skin lightening in healthy volunteers by reducing melanin distribution.
11 citations
,
May 2018 in “Philosophical Transactions of the Royal Society B” This review covers recent developments in materials for in vitro and in vivo stem cell manipulation, highlighting innovative substrate properties but does not report new experimental results.
11 citations
,
July 2014 in “Gene” This study reports a unique case of common variable immunodeficiency with autoimmunity linked to a heterozygous S250C variant in the autoimmune regulator gene, suggesting a potential molecular basis for this combination.
10 citations
,
January 2024 in “Polymer Chemistry” This review discusses the design and advances of lipid–polymer hybrid nanoparticles as promising delivery systems for genome editing strategies, highlighting their potential in biomedical applications.
6 citations
,
March 2021 in “International Journal of Pharmaceutics” This study reported that a subcutaneous injection formulation using PLGA microspheres to release finasteride stably achieved sustained monthly drug delivery without burst release in beagle dogs, with a dose of 16.8 mg identified as optimal for potential first-in-human trials.
4 citations
,
January 2022 in “Current pharmaceutical design” This review discusses the benefits and applications of microsponges delivery systems in drug delivery, particularly for topical treatments, and reports no new clinical findings.
3 citations
,
January 2024 in “Materials advances” This article reviews the properties of cellulose nanocrystals for sustainable development but presents no new experimental results.
3 citations
,
April 2018 in “Therapeutic Delivery” This editorial discusses advances in engineering techniques for hair follicle regeneration and highlights future potential but reports no original research findings.
2 citations
,
January 2026 in “Frontiers in Endocrinology” This review discusses the impaired functionality of regulatory T cells in the pancreas during the development of Type 1 diabetes, highlighting their role in disease pathogenesis, potential of Treg-based therapies, and challenges in clinical applications.
This study introduced Cadd4, a peptide-based degrader developed using computer-aided drug design, which effectively reduced PCSK9 levels and increased LDL receptor expression, resulting in decreased plasma cholesterol and LDL-C levels in hypercholesterolemic mice, without liver toxicity.
2 citations
,
June 2025 in “International Journal of Nanomedicine” This review examines emerging biomaterial strategies designed to support both neural regeneration and cutaneous wound healing, emphasizing their potential to improve sensory function through mechanisms like axonal regrowth and vascular network formation, while noting the need for standardized assessments and clinically translatable designs.
2 citations
,
June 2024 in “International Journal of Drug Delivery Technology” This review describes advanced drug delivery systems for dithranol aimed at overcoming stability issues and skin irritation seen in conventional formulations, highlighting options like nanoparticles and liposomes for improved psoriasis treatment.
2 citations
,
October 2015 in “Human Gene Therapy” The congress highlighted new gene therapy techniques and cell transplantation methods for treating diseases.
1 citations
,
May 2026 in “Signal Transduction and Targeted Therapy” This review highlights the promising role of stem cell therapy in treating resistant diseases, while also addressing the challenges in production and clinical application, emphasizing the need for standardized manufacturing and quality assurance to enhance efficacy and safety in clinical translational research.
1 citations
,
January 2026 in “Frontiers in Bioengineering and Biotechnology” This review discusses various nanocarriers for gene and genome editing therapies, highlighting that ionizable lipid nanoparticles show advanced delivery performance, while emerging polymer-based and exosome-inspired carriers are rapidly advancing for targeted applications.
1 citations
,
November 2025 in “Cell Death and Disease” This review discusses the role of various genetic regulators in maintaining human mesenchymal stem cell stemness and highlights strategies for ex-vivo expansion, but reports no new clinical findings.
1 citations
,
September 2025 in “Scientific Reports” This study reported that a colistin sulfate-loaded nanoemulgel showed improved antimicrobial activity and skin permeability compared to a CS solution, suggesting a potential new approach for treating severe infections caused by multidrug-resistant bacteria.
1 citations
,
August 2025 In this study, researchers evaluated drug-target interaction data from three major resources and developed a framework for drug repurposing, revealing associations between drug properties and therapeutic groups to aid in compound prioritization and predicting repositioning opportunities for existing drugs, particularly in cancer treatment.