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The nature of the side chain in RU 58841 derivatives greatly affects its AR affinity, with the N-(iodopropenyl) derivative 13 showing the highest AR binding affinity, suggesting its potential for developing high-affinity radioiodinated AR radioligands.

Scientists made the first metal-based compounds from a nonsteroidal antiandrogen drug, which showed potential in fighting both hormone-dependent and independent prostate cancer cells.

The document concludes that targeting 5α-reductase, the androgen receptor, and hair growth genes, along with using compounds with anti-androgenic properties, could lead to more effective hair loss treatments.

New treatments for prostate cancer are less toxic and show promise, but more research is needed to enhance their effectiveness and reduce side effects.

The p53 protein has complex, sometimes contradictory functions, including tumor suppression and promoting cell survival.

A new, less toxic and more efficient method to create the anti-baldness compound RU58841 was developed in 2014.

New nano composite helps reduce scars and regrow hair during burn wound healing.

Chitosan hydrogels are promising for repairing blood vessels but need improvements in strength and compatibility.

RU 58841 may treat acne, hair loss, and excessive hair growth.

RUM-loaded SLN shows promise for treating acne and hair loss topically.

Sebaceous glands in the skin play a key role in absorbing the antiandrogen drug RU 58841, especially when it's encapsulated in liposomes.

Liposomes can make the antiandrogen RU 58841 more effective for skin application by reducing absorption, increasing skin retention, and targeting sebaceous structures.

Testosterone can slow hair growth in adult monkeys, but a blocker called RU 58841 can counteract this and potentially help hair regrow.

Two non-steroidal antiandrogens, RU 58841 and RU 56187, form a common metabolite at different rates, which may influence their effects; RU 56187 could be used for prostate cancer treatment and RU 58841 for acne treatment.

Testosterone can slow down hair growth when combined with certain cells from bald scalps, and this effect can be blocked by an androgen receptor blocker.

Sex steroids, especially progesterone, can slow down the growth of mouse melanoma cells.

Scientists created iodinated arylhydantoins and arylthiohydantoins that could potentially be used for imaging prostate cancer. Some versions with specific side-chains showed high potential for this use.

Glucocorticoids and sex hormones affect skin health, with potential for targeted treatments to minimize side effects and treat skin conditions.

Scientists at the University of Michigan Medical School successfully created a special compound that can be used to improve imaging of prostate cancer.

Blocking CRF-R1 can reduce alcohol intake in stressed mice.

Exposure to certain sex hormones can increase health risks, while some hormone therapies may offer benefits for specific conditions.

Some systemic treatments work for nail psoriasis but can have serious side effects.

Researchers made stem cells from human hair follicle cells with higher efficiency than from skin cells.

The review says that stem cells are beneficial for making skin replacements.

Some epilepsy drugs can cause reproductive and cosmetic side effects in women and affect pregnancy, but most women still have healthy babies.

Both genetics and lifestyle factors contribute to male pattern baldness.

Metformin, a diabetes drug, may also help fight cancer, but more research is needed to understand how.

Male hormones may make COVID-19 worse, while substances that block these hormones could lessen symptoms.

Hirsutism and acanthosis nigricans are important for diagnosing PCOS; dermatologists play a key role in early detection and treatment.

The comprehensive treatment with biomimetic peptide lotion was effective for hair loss.