TLDR Male hormones may make COVID-19 worse, while substances that block these hormones could lessen symptoms.
The document "Androgens and Antiandrogens influence on COVID-19 disease in men" discusses the role of androgens (male hormones) and antiandrogens (substances that block these hormones) in the severity of COVID-19 in men. The paper suggests that high levels of androgens may increase the severity of COVID-19 symptoms, while antiandrogens could potentially reduce these symptoms. This is based on the observation that men with androgenetic alopecia, a condition characterized by high androgen levels, are more likely to experience severe COVID-19. Conversely, men undergoing antiandrogen therapy for conditions like prostate cancer seem to have milder COVID-19 symptoms. However, the paper emphasizes that more research is needed to confirm these findings and understand the underlying mechanisms.
119 citations,
May 2020 in “Journal of The American Academy of Dermatology” Most COVID-19 patients in hospitals have androgenetic alopecia, more in men, suggesting a link between androgen sensitivity and severe COVID-19 symptoms.
123 citations,
May 2020 in “Drug Development Research” Men's sensitivity to male hormones might affect how severe COVID-19 gets for them.
71 citations,
April 2020 in “Journal of Cosmetic Dermatology” Genetic differences may affect COVID-19 deaths; anti-androgens could be potential treatment.
113 citations,
July 2020 in “Communications biology” Men, especially older ones with health issues like prostate cancer, may have worse COVID-19 outcomes and could benefit from therapies targeting male hormones.
8 citations,
July 2012 in “Cambridge University Press eBooks” Androgens can both increase body hair and cause scalp hair loss.
7 citations,
December 2020 in “Clinics in Dermatology” Some alopecia treatments might help treat COVID-19, but more research is needed.
October 2020 in “Проблемы эндокринологии” Men with higher androgen levels may have severe COVID-19 symptoms, but those on antiandrogen therapy are less likely to contract the virus and have milder symptoms. Anti-androgen drugs could potentially treat COVID-19, but more research is needed.
1 citations,
January 2022 in “European Journal of Pharmacology” Riboflavin 5′-phosphate (FMN) shows potential for treating androgen-related conditions but may be limited in treating prostate cancer.
