Androgens and Antiandrogens Influence on COVID-19 Disease in Men

    December 2020 in “ Problemy e̊ndokrinologii
    Р. В. Роживанов, E. N. Andreeva, Г. А. Мельниченко, Н. Г. Мокрышева
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    TLDR Male hormones may make COVID-19 worse, while substances that block these hormones could lessen symptoms.
    The document "Androgens and Antiandrogens influence on COVID-19 disease in men" discusses the role of androgens (male hormones) and antiandrogens (substances that block these hormones) in the severity of COVID-19 in men. The paper suggests that high levels of androgens may increase the severity of COVID-19 symptoms, while antiandrogens could potentially reduce these symptoms. This is based on the observation that men with androgenetic alopecia, a condition characterized by high androgen levels, are more likely to experience severe COVID-19. Conversely, men undergoing antiandrogen therapy for conditions like prostate cancer seem to have milder COVID-19 symptoms. However, the paper emphasizes that more research is needed to confirm these findings and understand the underlying mechanisms.
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