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In this case study, researchers documented a Chinese boy with hair color changing to red and identified MC1R genetic mutations as the cause, rather than zinc deficiency, enhancing our understanding of hair heterochromia due to genetic factors.

Human platelets change minoxidil to minoxidil sulfate, helping blood vessels widen.

This study found that 2-hydroxy-1,4-naphthoquinone was the most effective inhibitor of steroid 5α-reductase, showing stronger inhibition than avicequinone C in HaCaT cell assays.

This study suggests that G. sibiricum has potent aldose reductase inhibitory activity, primarily due to kaempferol rhamnosides, and may be further explored as a natural treatment for diabetes-related complications.

This study suggests that using opioids along with 5αRI may reduce opioid use disorder risk in humans, supporting similar findings from animal studies.

This study found that the aromatic retinoic acid derivative Ro 10-9359 provided excellent results in 64% of severe psoriasis patients, especially in those with erythrodermic and pustular types, though relapses and side effects were noted.

This case report describes severe hypotension, acute coronary syndrome, tachycardia, and acute kidney failure in a man who ingested topical minoxidil, with eventual recovery following intensive treatment.

This study found that the synthesized compound 7b exhibited higher 5α-reductase inhibitory activity, increased solubility, and dissolution compared to finasteride, suggesting its potential as a lead compound for benign prostatic hyperplasia treatment.

In this study, a superoxide dismutase gel prevented hair graying in mice exposed to photosensitization, suggesting that antioxidants can protect against oxidative damage involved in hair aging.

This study found that the retinoic acid derivative Ro 10-9359 cleared psoriasis lesions in over half of the patients, but most experienced side effects, including skin issues and altered liver enzyme levels.

This review discusses the potential of using triads of repositioned medicines targeting multiple pathogenic mechanisms to prevent or delay retina degeneration, but reports no new results.

In this chemical investigation, cyclospongiaquinone 1 from the sponge Verongula cf. rigida showed strong steroid 5α-reductase inhibitory activity, comparable to that of finasteride.

This study explored the role of plant-derived monomers in reversing grey hair, finding that compounds like fraxinol and morin may stimulate melanin production and tyrosinase activity, suggesting potential therapeutic benefits, although further evaluation of their safety and efficacy is needed.

This study found that in sleep-deprived rats, increased 5α-reductase expression and activity in the prefrontal cortex contributed to psychosis- and mania-like symptoms, which finasteride ameliorated in a dose-dependent manner.

This review highlights recent progress in developing androgen receptor degraders, such as PROTACs, for treating castration-resistant prostate cancer, and notes that several have entered phase I or II clinical trials, showcasing potential to address drug resistance challenges.

This study found that minoxidil increases cytosolic-free Ca2+ levels and induces cytotoxicity in PC3 human prostate cancer cells, with the cytotoxicity occurring in a Ca2+-independent manner.

This study found that male 5α-reductase 2 knockout mice showed deficits in social dominance behaviors and reduced dopamine receptor binding in a brain region related to social ranking.

This study found that vitamin A treatment in rats reduced hyperplastic-dysplastic changes and sebaceous gland hypertrophy associated with 3,4-benzpyrene-induced tumors.

This research article focuses on nonsteroidal inhibitors of human type I steroid 5-alpha-reductase but reports no new results.

This study by Pérez-Oliva et al. explored how Mahogunin Ring Finger-1 (MGRN1) affects melanocortin-1 receptor (MC1R) signaling, suggesting that MGRN1 competitively inhibits Gαs binding to MC1R, influencing pigment production.

This study found that hydrogen peroxide accumulation and reduced methionine sulfoxide repair play a significant role in the oxidative damage linked to senile hair graying.

This review highlights the need for a deeper understanding of 5alpha-reductases and neuroactive steroids to reduce potential adverse effects of 5alpha-reductase inhibitors used for conditions like benign prostatic hyperplasia and androgenic alopecia, but reports no new clinical results.

This study found that minoxidil increased plasma renin activity in patients with hypertension through both an adrenergic mechanism related to heart rate changes and a secondary mechanism unrelated to propranolol.

This study provides evidence supporting the theory that the presence of selenocysteine in proteins, such as thioredoxin reductase, may confer chemical reversibility, which contributes to their oxidative resistance and potential catalytic functions.

This review discusses FAERS data on 5-alpha reductase inhibitors and their potential implications for post-finasteride syndrome, but it does not report any new clinical results.

This study reports that structural and biochemical analysis of steroid 5α-reductases clarifies how they mediate steroid reduction with NADPH, potentially aiding in designing targeted therapies.

This study found that emodin from Polygonum multiflorum showed 5alpha-reductase inhibitory activity, which was more potent than alizarin but less potent than riboflavin.

This study found that finasteride significantly reduced serum dihydrotestosterone levels, confirming its efficacy as a 5a-reductase inhibitor, while Permixon showed no effect in healthy male volunteers.