Treatment of Psoriasis Vulgaris with a New Retinoic Acid Derivative Ro 10-9359

    January 1977 in “ Dermatology ”
    Birgit Dahl, Kirsten Møllenbach, Flemming Reymann
    TLDR The treatment cleared psoriasis in some patients but caused side effects in most.
    The study investigated the effects of the retinoic acid derivative Ro 10-9359 on 15 patients with psoriasis vulgaris, administering up to 100 mg daily. After an average treatment period of 9 weeks, 8 patients experienced clearing of lesions. However, 14 patients reported side effects, including palmo-plantar desquamation, shivering, thirst, and diffuse hair loss. Two patients discontinued due to scaling, and 6 patients showed abnormal liver enzyme values, with some being transient.
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