Antipsoriatic Activity of a New Synthetic Retinoid
September 1983
in “
Archives of dermatology
”
Studysummary This study observed that minimal doses of the arotinoid RO 13-6298 successfully treated two cases of severe psoriasis and psoriatic arthritis unresponsive to traditional therapies, despite some side effects. Our plain-language summary of this paper — not a Tressless recommendation.
Two patients with severe generalized psoriasis and psoriatic arthritis, unresponsive to traditional treatments including etretinate and PUVA, were successfully treated with minimal oral dosages of the new synthetic retinoid arotinoid RO 13-6298 (0.05 to 0.1 mg/day). Side effects included dryness of the lips and nasal mucosa, palmarplantar desquamation, skin thinning, itching, and transient hair loss, but no laboratory abnormalities were found. RO 13-6298 appeared to be a highly potent antipsoriatic agent effective at very low doses.
