TLDR The new synthetic retinoid RO 13-6298 effectively treated severe psoriasis at low doses with manageable side effects.
Two patients with severe generalized psoriasis and psoriatic arthritis, unresponsive to traditional treatments including etretinate and PUVA, were successfully treated with minimal oral dosages of the new synthetic retinoid arotinoid RO 13-6298 (0.05 to 0.1 mg/day). Side effects included dryness of the lips and nasal mucosa, palmarplantar desquamation, skin thinning, itching, and transient hair loss, but no laboratory abnormalities were found. RO 13-6298 appeared to be a highly potent antipsoriatic agent effective at very low doses.
21 citations,
June 1990 in “British Journal of Dermatology” Systemic retinoids are effective for psoriasis but have side effects; benefits may outweigh risks, especially when reducing cancer risks from other treatments.
31 citations,
January 1981 in “Pharmacology & Therapeutics” Oral retinoids are effective for treating severe skin disorders but have reversible side effects and risks for pregnant women.
February 1990 in “Journal of The American Academy of Dermatology” New skin treatments in 1987-1988 showed effectiveness for various conditions, but some had side effects or risks.
August 1986 in “Journal of The American Academy of Dermatology” Minoxidil showed a 30% success rate for hair growth in a study, and various skin treatments were effective, but some had limitations or side effects.
29 citations,
March 1983 in “Journal of The American Academy of Dermatology” New treatments for psoriasis have improved effectiveness and may reduce long-term side effects when combined with standard therapies.
