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The authors describe drug repurposing as a promising strategy for finding new uses for existing drugs, noting it is efficient, cost-effective, and poses lower risks than traditional drug discovery processes, potentially aiding in the treatment of rare and difficult-to-treat diseases.

This study used a zebrafish model and advanced mass spectrometry to identify 11 metabolites of epristeride, revealing significant effects on purine metabolism and aromatic amino acid biosynthesis, which may aid in developing anti-doping detection methods.

This review explores the role of neurosteroids in affective disorders, highlighting existing research on their impact on mood and discussing emerging evidence that endogenous neurosteroids may influence baseline emotional states.

In this study, a systematic review highlighted the potential of exosomes in cosmetics and regenerative medicine for improving skin rejuvenation and addressing aging, while also pointing out existing challenges such as regulatory hurdles and the need for more clinical validation.

This study found that melatonin may enhance hair follicle stem cell viability by downregulating the nuclear receptor RORA, which otherwise inhibits cell proliferation and promotes apoptosis.

This chapter highlights the potential of exosomes as innovative agents in cosmetic dermatology, noting their ability to promote skin rejuvenation and target issues like wrinkles, photoaging, and hair loss.

This study used an in silico/in vitro approach to identify potential inhibitors of the enzyme SRD5A2, finding that the androgen receptor modulator MK-0773 is a moderate inhibitor, although it does not act as a covalent inhibitor like finasteride.

This narrative review highlights the potential of exosomes as a promising platform for precision diagnostics, regenerative medicine, and targeted therapeutics in dermatology, while noting challenges such as standardization, manufacturing, and regulatory approval that must be resolved before widespread clinical use.

The researchers reported that during early embryogenesis and larval development in Silurana tropicalis, inhibiting steroidogenic enzymes cyp19 and srd5beta affects genes related to thyroid and reproductive systems.

This study reports that structural and biochemical analysis of steroid 5α-reductases clarifies how they mediate steroid reduction with NADPH, potentially aiding in designing targeted therapies.

This review discusses the evolution of platelet concentrates in regenerative medicine, highlighting a proposed function-driven classification that distinguishes three generations of PCs by biological activity rather than development order, with third-generation exosome-based therapies showing superior therapeutic efficacy over earlier formulations.

This study found that dexpanthenol treatment reduced inflammation, oxidative stress, and apoptosis in rats, providing a protective effect against lipopolysaccharide-induced cardiac and endothelial damage.

This study developed and validated a reverse phase liquid chromatography method to accurately and reliably measure Minoxidil and Finasteride in bulk and marketed formulations.

In this study, a topical lotion containing Redensyl and Sepicontrol A5 demonstrated effectiveness for treating androgenetic alopecia over 24 weeks, with 73.1% of users seeing moderate improvement and notable increases in hair cycle ratios, alongside enhanced quality of life and satisfaction.

In this study, researchers found that overexpressing SOX2 in colorectal cancer cell lines can cause DNA damage and cell death, while repressing it reduces tumor growth and cell aggressiveness.

This study found that cortisone reductase deficiency is caused by inactivating mutations in the H6PD gene, affecting cortisol metabolism by preventing 11β-HSD1 enzyme function.

This report describes two cases of Rapp–Hodgkin ectodermal dysplasia where refractory scalp erosions improved significantly with potent topical steroids; it also suggests a potential link between these scalp conditions and erosive pustular dermatosis of the scalp in elderly patients.

This article discusses the potential of mesenchymal stem cell-derived exosomes (MSCs-exosomes) in regenerative medicine, highlighting their beneficial effects like anti-inflammatory and tissue regeneration properties, and noting challenges such as exosome isolation and safety evaluation that need addressing.

This study found that using mineralocorticoid receptor antagonists with glucocorticoid therapy improved wound healing in diabetic animals by enhancing keratinocyte proliferation and epithelialization.

This study highlights the approval of orforglipron under the FDA's National Priority Voucher program, emphasizing its significance as a convenient oral treatment option with beneficial effects on glycemic and lipid profiles for diabetes and obesity management.

This study suggests that in human osteoblast-like cells, the 5alpha-reductase type 1 isozyme predominantly catalyzes the conversion of testosterone to DHT, which may play a role in bone homeostasis.

This study found that strontium ranelate may promote cartilage regeneration by enhancing chondrogenic differentiation and inhibiting the Wnt/β-catenin signaling pathway in rat models of cartilage defects.

This review discusses emerging research on the transcription factor Sox6 and its roles in cardiovascular and kidney function, highlighting its involvement in diseases such as cardiomyopathy and diabetes; it reports no new experimental findings.