Mineralocorticoid Receptor Antagonists: A New Sprinkle of Salt and Youth

The document discussed the potential benefits of mineralocorticoid receptor (MR) antagonists in improving skin health and wound healing, particularly in the context of aging and glucocorticoid (GC) treatment. Studies in mouse models and human skin explants indicated that MR antagonists like spironolactone and eplerenone could suppress cutaneous aging, enhance wound closure, and increase skin elasticity by modulating MR activity. These findings suggested that MR-targeted therapies might counteract the adverse effects of excess cortisol and GC treatment, offering both clinical and cosmetic benefits. However, further research was needed to confirm these benefits in patients with chronic conditions requiring systemic steroid treatment.