The Mineralocorticoid Receptor Plays a Transient Role in Mouse Skin Development

    August 2015 in “ Experimental Dermatology ”
    Julia Boix, Elena Carceller, Lisa M. Sevilla, Víctor Marcos‐Garcés, Paloma Pérez
    TLDR The mineralocorticoid receptor temporarily affects mouse skin development, but the glucocorticoid receptor has a more lasting impact.
    The study investigated the role of the mineralocorticoid receptor (MR) in mouse skin development, focusing on its expression during embryonic stages and its impact on epidermal differentiation. MR expression peaked at embryonic day 16.5 (E16.5) and decreased thereafter, suggesting a transient role in skin maturation. MR−/− mice exhibited increased epidermal thickness and altered differentiation, but these changes resolved postnatally, indicating potential compensation by the glucocorticoid receptor (GR). The study concluded that MR plays a temporary role in epidermal development, with GR possibly compensating for MR loss during the perinatal period. The findings highlighted the distinct regulatory roles of MR and GR in skin development, with GR having a more critical function in maintaining epidermal integrity.
    Discuss this study in the Community →

    Research cited in this study

    3 / 3 results

    Related Community Posts Join

    6 / 6 results

      community When someone posts a scalp tension theory

      in Satire  264 upvotes 4 years ago
      Hair loss theories discussed include poor blood flow, scalp tension, inflammation, and DHT. Treatments mentioned are massaging scalp, minoxidil, finasteride, and RU58841.

      community New and Interesting HairLoss Studies/Papers/Reviews

      in Treatment  40 upvotes 5 years ago
      Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.

      community Group Buy for MR antagonist finerenone

      in Product  11 upvotes 2 years ago
      User discusses group buy for finerenone, a third-gen mineralocorticoid antagonist for hair loss treatment. Finerenone inhibits TGFb, NOX, and ROS, and improves renal and cardiac function; topical dose should be no more than 10mg per day.

      community Dutasteride is amazing even for women with FAGA!

      in Female  151 upvotes 3 months ago
      Dutasteride significantly improved hair health and reduced shedding for a woman with PCOS and hyperandrogenism, without causing depression or anxiety, unlike finasteride. Dutasteride also helped with PMDD symptoms and had no side effects, though it changed hair texture.

      community risks with finasteride and dutasteride

      in Research/Science  144 upvotes 4 months ago
      Finasteride and dutasteride have potential risks, including post-finasteride syndrome, but are commonly used for hair loss. RU58841, minoxidil, and needling are suggested as alternatives, though all treatments carry risks.

    Similar Research

    5 / 434 results