Efficacy of Spironolactone as Adjunctive Therapy to Sodium Valproate in Bipolar-I Disorder: A Double-Blind, Randomized, Placebo-Controlled Clinical Trial

    November 2023 in “ Brain and behavior ”
    Atefeh Zandifar, Rahim Badrfam, Fatemeh Gholamian, Arman Shafiee
    Studysummary This study found that spironolactone improved cognitive performance in patients with bipolar disorder experiencing manic episodes, but did not significantly affect manic symptoms, recommending further research with larger sample sizes and longer follow-ups.
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    Research cited in this study 5

    1. Efficacy of Spironolactone as Adjunctive Therapy to Sodium Valproate in Bipolar-I Disorder: A Double-Blind, Randomized, Placebo-Controlled Clinical Trial Brain and behavior · 2023
    2. Association of Spironolactone Use With Risk of Cancer: A Systematic Review and Meta-Analysis JAMA Dermatology · 2022
    3. Spironolactone in Dermatology Dermatologic Therapy · 2022
    4. Spironolactone in Dermatology: Uses in Acne and Beyond Clinical and Experimental Dermatology · 2020
    5. Spironolactone and XPB: An Old Drug with a New Molecular Target Biomolecules · 2020