TLDR Spironolactone improved cognitive performance and early sleep quality but not manic symptoms, appetite, or body weight in bipolar disorder when added to sodium valproate.
The double-blind, randomized, placebo-controlled clinical trial involving 60 patients with bipolar disorder type 1 investigated the efficacy of spironolactone as an adjunctive therapy to sodium valproate. The study found that spironolactone significantly improved cognitive performance by the eighth week of the trial compared to the placebo group. However, there were no significant differences between the two groups in terms of manic symptoms, appetite, or body mass index. The study also found that spironolactone improved sleep quality by the fourth week, but this effect was not seen in the eighth week. The authors suggest further studies with larger sample sizes and longer durations to better understand the potential benefits of spironolactone in treating manic episodes of bipolar disorder.
1 citations
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November 2023 in “Brain and behavior” Spironolactone improved cognitive performance and early sleep quality but not manic symptoms, appetite, or body weight in bipolar disorder when added to sodium valproate.
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February 2022 in “JAMA Dermatology” Spironolactone does not increase cancer risk and may lower prostate cancer risk, but more research is needed.
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January 2022 in “Dermatologic Therapy” Spironolactone is useful for treating acne and other skin conditions like excessive hair growth and certain types of hair loss.
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May 2020 in “Biomolecules” Spironolactone, a heart and liver drug, has new uses including cancer treatment, viral infection prevention, and skin condition improvement.
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