Dexpanthenol Ameliorates Lipopolysaccharide-Induced Cardiovascular Toxicity by Regulating the IL-6/HIF1α/VEGF Pathway

The study investigated the effects of Dexpanthenol (Dex) on lipopolysaccharide (Lps)-induced cardiovascular toxicity in 32 male Wistar Albino rats. Dex was found to reduce inflammation, oxidative stress, and apoptosis in heart and aortic tissues by modulating the IL-6/HIF1α/VEGF pathway, as evidenced by decreased levels of HIF1α, IL-6, TNFα, and VEGF. The study concluded that Dex has a protective effect against Lps-induced cardiac and endothelial damage, suggesting its potential as a valuable adjuvant in treating sepsis due to its anti-inflammatory and antioxidant properties. Further research is needed to explore its effects on other signaling pathways.