Investigation of the Effects of Dexpanthenol on Brain Tissue in Experimental Global Cerebral Ischaemia-Reperfusion Injury

The study investigated the effects of dexpanthenol on brain tissue in a model of global cerebral ischemia-reperfusion injury using 32 female Wistar-Albino rats. The rats were divided into four groups, and their brain tissues were analyzed after 72 hours of reperfusion. Results showed that dexpanthenol significantly improved motor skills and reduced neuronal damage in the ischemia-reperfusion groups treated with dexpanthenol compared to the untreated group. While there were no significant differences in CAT, SOD, and GPx enzyme levels, malondialdehyde (MDA) levels decreased, and glutathione (GSH) levels increased in the dexpanthenol-treated groups. The findings suggest that dexpanthenol has a neuroprotective effect, particularly when administered during reperfusion.