research Neutrophil Extracellular Traps Impair Regeneration
Neutrophil extracellular traps slow down hair follicle healing after injury.
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research Exploring the Relationship Between Acne and Mental Health
Acne is genetically linked to a higher risk of depression, anxiety, schizophrenia, and bipolar disorder, with the strongest link to bipolar disorder.
research Allosteric Interactions Prime Androgen Receptor Dimerization And Activation
Certain interactions help prepare the androgen receptor for pairing and activation, which is important for its role in development and disease.
research Overlaps Between Inflammatory Dermatoses and Ichthyoses: Need for Novel Therapeutic Approaches
Patients with ichthyosis often experience symptoms similar to psoriasis and atopic dermatitis, suggesting that targeted therapies could improve their condition.
research The Early Region of Trichodysplasia Spinulosa Polyomavirus Drives Proliferation, Altered Differentiation, and Ectopic Expression of Hair Follicle Differentiation Markers in Interfollicular Tail Epidermis
The early genes of a specific virus can cause abnormal skin cell growth and hair follicle changes.
research Thymic Stromal Lymphopoietin Controls Hair Growth
Thymic stromal lymphopoietin (TSLP) promotes hair growth by stimulating specific skin cells.
research British Menopause Society Tools for Clinicians: Testosterone Replacement in Menopause
Testosterone replacement can help menopausal women with various symptoms, but should be used carefully and is not yet officially licensed in the UK for women.
research UVB Irradiation with Anti-CD154 Antibody Prolonged the Survival of Hair Follicle Allografts in Humanized Mice
Combining UVB irradiation and anti-CD154 antibody improves hair follicle transplant survival.
research Single-Cell Transcriptomic Profile of EGFR-Deficient Epidermal Compartments During Folliculitis
EGFR deficiency causes significant changes in skin cells and hair follicles.
research P21Waf1/Cip1 Is Differentially Expressed in Epidermal Versus Follicular Melanocytes and Melanoma Cells and Is Phenotypically Regulated by UVB-Mediated Apoptosis
The protein p21 is more abundant in normal skin cells than in melanoma cells and may help protect against melanoma, with UVB light affecting its levels.
research Noncoding dsRNA Stimulates Exosome Biosynthesis to Regulate Skin Regeneration
Noncoding dsRNA helps produce exosomes that aid in skin regeneration.
research The Possible Role of PTEN-Induced Kinase 1-Mediated Mitophagy in Regulating Inflammasome Activation in the Pathogenesis of Alopecia Areata
Activating mitophagy may help manage a key immune response involved in the hair loss condition alopecia areata.
research The Wnt-Inhibitor Dkk4 Is Required for Primary Hair Follicle Induction and Patterning
Dkk4 protein is necessary for the proper development and arrangement of hair follicles.
research FDA Reports of Alopecia as an Adverse Event to Isotretinoin
Isotretinoin may cause hair loss, especially in women and young adults.
research 067 BELCOMID: Belgian Cohort Study of COVID-19 in Immune Mediated Inflammatory Diseases
COVID-19 infection rates were low in patients with immune diseases, regardless of their treatment type.
research Comparison of Ruxolitinib and a Collagen-Targeted PTH-Based Hair Cycle Stimulant on Hair Follicle Counts and Hair Growth in the C3H/HeJ Engrafted Mouse Model of Alopecia Areata
A PTH-based treatment improved hair regrowth better than ruxolitinib in a mouse model of hair loss.
research Understanding Immune Privilege in an Inducible Mouse Model of Primary Cicatricial Alopecia
The study found that a key immune pathway protecting hair follicles is reduced in a mouse model of scarring hair loss.
research Low-Intensity Ultrasound Protects Human Scalp Hair Follicles From Taxane-Induced Toxicity
Low-intensity ultrasound may protect hair follicles from damage caused by a common chemotherapy drug.
research The 5α-Reductase Inhibitor Finasteride Reduces Opioid Self-Administration
Finasteride may help reduce opioid use.
research Pathological Modeling of Epidermolysis Bullosa Simplex Using Induced Pluripotent Stem Cells
Scientists used stem cells to create a model of the skin disease Epidermolysis Bullosa simplex, which helped them understand its molecular mechanisms and could aid in finding treatments.
research Development of a Complex Skin Organ in Human Induced Pluripotent Stem Cell-Derived Organoids
Scientists created skin-like structures from stem cells that include features like hair and sweat glands.
research Characterization of Novel TMEM173 Mutation Causing a Lupus- and SAVI-Like Phenotype, Modified by Polymorphisms in TMEM173 and IFIH1
A new mutation in the STING protein causes a disease with lupus-like symptoms and responds well to a specific inhibitor treatment.
research Fifteen-Minute Consultation: Approach to the Adolescent Presenting with Hirsutism
Hirsutism in teens is often due to polycystic ovarian syndrome and needs careful assessment and support.
research Commentary on Clinical Use of Extracellular Vesicles in the Management of Male and Female Pattern Hair Loss: A Preliminary Retrospective Institutional Review Board Safety and Efficacy Study
research Polycomb-Mediated Repression and Sonic Hedgehog Signaling Regulate Merkel Cell Specification
Sonic hedgehog signaling is needed for the development of touch-receptor cells in the skin, and the loss of Polycomb repressive complex 2 can lead to more of these cells.
research Bifidobacterium Is Enriched in Gut Microbiome of Kashmiri Women with Polycystic Ovary Syndrome
Kashmiri women with PCOS have more Bifidobacterium in their gut.
research Mapping the Global Landscape of Therapeutic Patient Education and Self-Management Support Programs in Psoriasis: A Qualitative Study
There are various tools available to help psoriasis patients manage their condition, but their effectiveness is unclear and they face issues like lack of financial support.
research Prostaglandin D2-Enhanced Testosterone Metabolism in Human Keratinocytes Is Mediated by Reactive Oxygen Species
Prostaglandin D2 increases testosterone levels in skin cells through reactive oxygen species, not enzymes, which could lead to new hair loss treatments.
research Cardiovascular Profile of Pharmacological Agents Used for the Management of Polycystic Ovary Syndrome
Medications for PCOS don't seem to raise heart disease risk.
research Obesity and Polycystic Ovary Syndrome: Implications for Pathogenesis and Novel Management Strategies
Obesity worsens PCOS symptoms, and PCOS may lead to more weight gain; managing both requires a holistic approach that includes mental health.