Exploring the Relationship Between Acne and Mental Health

November 2022 in “ Journal of Investigative Dermatology ”

Brittany L. Mitchell, J. Saklatvala, N.G. Martin, C. Smith, J. Barker, M. Renteria, Matilda Simpson

acne vulgaris genetic correlation genome-wide association studies depression anxiety schizophrenia bipolar disorder genetic risk score causal relationship co-morbidity acne genetic overlap GWAS mental health disorders

TLDR Acne is genetically linked to a higher risk of depression, anxiety, schizophrenia, and bipolar disorder, with the strongest link to bipolar disorder.

The document "306 Exploring the relationship between acne and mental health" investigates the genetic overlap between acne vulgaris and seven mental health disorders, using the largest available genome-wide association studies. The study found a significant genetic correlation between increased risk of acne and increased risk of depression, anxiety, schizophrenia, and bipolar disorder, with the strongest correlation with bipolar disorder (rg = 0.18; P=6.7e-05). An acne genetic risk score also significantly predicted a reported history of depression, anxiety, and bipolar disorder (P<0.001). Furthermore, a causal relationship was observed between increased risk of acne and increased risk of depression (OR=1.04 [95% CI 1.02-1.07]). The study concludes that the co-morbidity between these disorders may be genetically mediated, providing new insights into the relationships and underlying mechanisms between acne and mental health disorders.

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