Allosteric Interactions Prime Androgen Receptor Dimerization And Activation
February 2022
in “
bioRxiv (Cold Spring Harbor Laboratory)
”
androgen receptor AR steroid receptor transcription factor prostate epithelium muscle tissue male phenotype prostate cancer reconstitution biochemistry cryo-electron microscopy DNA binding non-obligate dimer nuclear receptors allosteric communication partial androgen insensitivity syndrome PAIS oncoprotein cofactor ERG DNA binding site motifs transcriptional activation
Preprint — not peer reviewed. This was posted to a preprint server or data repository. It has not been through a journal's review process, and its findings may change or not hold up.
Studysummary This study uses cryo-electron microscopy to reveal how androgen receptor forms a non-obligate dimer to bind DNA, with implications for prostate cancer development.
Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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