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Insulin resistance and obesity are key factors in the development and worsening of polycystic ovary syndrome, and lifestyle changes are important for managing it.

The skin is a complex barrier for drug penetration, but understanding its structure and interactions can improve drug delivery methods.

The document concludes that developing generic topical drugs requires ensuring they match the original in quality, composition, and structure, and often involves complex testing and regulatory steps.

Caffeine in cosmetics may reduce cellulite, protect skin, and stimulate hair growth, but more research is needed on its use and effects.

Fat-derived stem cells show promise for skin repair and reducing aging signs but need more research for consistent results.

Obesity worsens PCOS symptoms, and PCOS may lead to more weight gain; managing both requires a holistic approach that includes mental health.

Hormones, especially androgens, play a big role in acne, but most acne sufferers don't have a hormone disorder. Hormonal treatments, including birth control pills, can be very effective for women whose acne doesn't improve with regular treatments.

Researchers identified genes linked to coat color, body size, cashmere production, and high altitude adaptation in goats.

All-trans retinoic acid causes hair loss by increasing TGF-β2 in hair follicle cells.

Obesity increases the risk of developing polycystic ovary syndrome, and weight loss can improve the condition.

Correcting nutrient deficiencies may help with hair loss, but the benefits of supplements without a deficiency are uncertain and could be harmful.

New genes and pathways are important for testosterone production and male sexual development.

PCOS affects women's health by increasing the risk of diabetes, heart disease, and reproductive issues.

Anti-acne medications may work by reducing the activity of a protein involved in acne development.

Obese women with PCOS show a male-like pattern in certain fat tissue gene expressions.

The document concludes that recognizing and properly diagnosing lipodystrophy syndromes is crucial for effective management and treatment.

Women with regular menstrual cycles and PCOS have linked kisspeptin and LH hormone patterns, unlike those with irregular cycles.

The enzyme 17β-HSD type 2 mainly performs oxidation in human sebaceous glands, which may help protect against acne.

High levels of androgens during early development may cause PCOS-like symptoms.

Genetics play a role in acne, but how exactly they contribute is not fully understood.

Melatonin helps Cashmere goats grow more hair by affecting certain genes and cell pathways.

Caffeine applied to the scalp can protect hair follicles from UV damage.

Low testosterone and 5α-reductase inhibitors can harm men's metabolic and sexual health; testosterone therapy may help, but discussing 5α-RIs' side effects is important.

Diagnosing PCOS in teenagers is hard because its symptoms often look like normal puberty, and there's a need for better diagnosis methods and agreement on criteria.

Researchers found new genes involved in hair growth, which could help develop new hair treatments.

Hormonal treatment is effective for women with acne not helped by usual treatments, especially if they have hormonal imbalances.

Using defensins to activate stem cells may improve skin aging signs without causing inflammation.

Facial aging is caused by natural processes and external factors, and can be managed with preventative measures and a variety of treatments tailored to individual needs.

The composition with carnitine, thioctic acid, and saw palmetto extract may effectively reduce inflammation in hair follicle cells.

Obese and non-obese women with PCOS have higher heart risk markers, especially if they are obese.