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Mice without certain skin enzymes have faster hair growth and bigger eye glands.

Enzymes involved in Vitamin A metabolism affect hair growth and type in mice.

Maintaining the right amount of retinoic acid is crucial for healthy hair and skin.

Altered retinoid metabolism in cicatricial alopecia suggests a balanced vitamin A diet may prevent the condition.

Systemic retinoids are effective for psoriasis but have side effects; benefits may outweigh risks, especially when reducing cancer risks from other treatments.

Sdr16c5 and Sdr16c6 genes regulate a key point in lipid production that affects eye and skin gland function.

Retinoic acid affects male and female muscle energy use and function differently.

Vitamin A is important for healthy skin and hair, influencing hair growth and skin healing, but UV light reduces its levels.

Estrogen affects how vitamin A is processed in mouse skin, which may impact acne treatment, hair growth, and skin defense.

The ABCA4 gene protects hair follicle stem cells from toxic vitamin A byproducts.

Eating too much or too little vitamin A can cause hair loss.

Retinoic acid-binding proteins in skin are regulated by β-catenin and Notch signalling.

Vitamin A affects hair loss and immune response in alopecia areata.

The right amount of retinoic acid is essential for normal hair growth and development.

DGAT1 enzyme is crucial for healthy skin and hair by regulating retinoid levels.

The enzyme RDH12 plays a role in vision and retinal disease, with mutations leading to early onset visual loss and blindness, but the exact disease mechanism is unclear and there are no treatments yet.

Two enzymes regulate androgen receptor activity, affecting treatments for androgen insufficiency and benign prostatic hyperplasia.

Turning white fat into brown-like fat could help fight obesity and type 2 diabetes.

Dehydroepiandrosterone (DHEA) is a prohormone important for producing sex steroids and has potential health benefits.

Creating stronger blockers for skin enzymes might lead to better treatment for conditions like acne and excessive hair growth.

Hormones, especially androgens, play a big role in acne, but most acne sufferers don't have a hormone disorder. Hormonal treatments, including birth control pills, can be very effective for women whose acne doesn't improve with regular treatments.

New genes and pathways are important for testosterone production and male sexual development.

The enzyme 17β-HSD type 2 mainly performs oxidation in human sebaceous glands, which may help protect against acne.

Different species and human skin models vary in their skin enzyme activities, with pig skin and some models closely matching human skin, useful for safety assessments and understanding the skin's protective roles.

The enzymes 5α-reductase and 3α/β-hydroxysteroid oxidoreductase help create brain-active substances from progesterone and testosterone, which could be used for treatment, but more research is needed to ensure their safety and effectiveness.

Researchers found that most genes affecting drug responses are not fully covered by commercial SNP chips, suggesting the need for more comprehensive tools to optimize drug selection based on genetics.

Activating TLR3 may help produce retinoic acid, important for tissue regeneration.

Genetic defects in testosterone production can cause hormonal and developmental disorders, and more research is needed to understand androgen regulation and develop safer treatments.

Different enzymes are active in different parts of developing mouse organs.

DHT in the human prostate is produced through multiple pathways, not just from testosterone.