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A Chinese family had a child with a specific gene mutation causing vitamin D-resistant rickets, but the child improved with calcium and low-dose calcitriol.

Pigs without the Hairless gene showed skin and thymus changes, useful for studying human hair disorders.

SHISA6 helps maintain certain stem cells in mouse testes by blocking signals that would otherwise cause them to differentiate.

Damaged hair follicles make mice more prone to skin inflammation and skin cancer after UV exposure.

Topical patidegib gel effectively treats basal cell carcinoma in Gorlin syndrome patients without causing the side effects seen with oral treatments.

The 190-kbp domain contains all human type I hair keratin genes, showing their organization and evolution.

Hidradenitis suppurativa may be related to hormones and patients often have metabolic disorders; more research is needed to understand this connection.

Genomic approach finds new possible treatments for hair loss.

The cornified envelope is crucial for skin's barrier function and involves key proteins and genetic factors.

Isotretinoin therapy for acne can cause many reversible side effects, mainly mild skin conditions, and patient understanding of these effects can improve treatment adherence.

Mice without the vitamin D receptor have bone issues and other health problems, suggesting vitamin D is important for preventing various diseases in humans.

A substance called VIP might protect hair follicles from being attacked by the immune system, and problems with VIP signaling could lead to hair loss in alopecia areata.

Melatonin applied to the scalp helps treat early-stage hair loss in men and women.

Melatonin applied to the scalp helps increase hair density in people with early hair loss.

A new mutation in the hairless gene causes hair loss and skin wrinkling in mice.

An imbalance between certain immune cells is linked to a chronic skin condition and may be influenced by obesity, smoking, and autoimmune issues.

Environmental factors like diet and vitamin levels, especially Vitamin D, can affect autoimmune diseases differently, with lifestyle changes potentially improving outcomes.

Increased HIF-1α is linked to the inflammation and severity of hidradenitis suppurativa, suggesting treatments that lower HIF-1α could help.

Hidradenitis Suppurativa is a chronic skin condition best treated early with surgery for better outcomes and less recurrence.

Disrupting natural body clocks increases the risk of developing type 2 diabetes.

BMAL1 controls skin cell growth and UV damage risk, peaking at night.

Circadian clock genes are important for hair growth and may affect aging-related hair loss and graying.

Hairless protein affects hair follicle structure by regulating the Dlx3 gene.

Melatonin, usually known for sleep regulation, also has antioxidant properties that can protect skin, stimulate hair growth, and improve skin conditions, with topical application being more effective than oral use.

Intestinal intraepithelial lymphocytes are crucial for gut immunity and maintaining the mucosal barrier.

Melatonin, the sleep hormone, can help treat skin conditions like dermatitis, hyperpigmentation, and scalp disorders, and may also aid in skin aging prevention and regeneration. However, it's not recommended for asthma due to its pro-inflammatory effect.

Melatonin could be an effective treatment for Alzheimer's Disease and rosacea.

B6.Cg-Tyr c−2J Hr hr /J mice have a stronger delayed sunburn reaction and are good for UV research.

Natural skincare products may help reduce sun damage and support the skin's daily cycle.