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This symposium reviewed strategies to advance stalled drug molecules, discussed common regulatory hurdles, and explored options for repurposing drugs, but it reported no new research findings.

This study identified new potential targets and indications for several marketed drugs using in silico profiling, suggesting opportunities for drug repositioning.

This review discusses the role of the TOR pathway in aging and suggests that rapamycin could potentially target age-related diseases, but reports no new clinical results.

This review discusses melatonin's potential in dermatology, highlighting its antioxidative, immunomodulatory, and DNA repair properties, but reports no new clinical results.

Finasteride increases hair density in female androgenetic alopecia, but individual results may vary.

This study observed that the ethyl acetate extract of Equisetum debile showed high activity against 5α-reductase and lipid peroxidation with no cytotoxicity on dermal papilla cells.

The article concludes that the global hair trade is exploitative and reflects complex cultural and economic issues.

This study found that inhibiting 5α-reductase in molluscs provokes a specific shell morphology, suggesting gastropods might have unique 5α-reductase substrates absent in vertebrates.

This review discusses the potential role of vitamin D deficiency in cardiovascular and renal diseases and suggests that supplemental vitamin D could benefit cardiovascular outcomes, especially in African American and postmenopausal women; it reports no new clinical findings.

This study found that 11α-hydroxyprogesterone is a potent inhibitor of 11βHSD2 in vitro and may serve as a precursor to unique C11α-hydroxy steroids in prostate cancer tissue.

In this study, researchers identified loss of function variants in the HR gene as likely causes of the distinct roaning hair coat seen in lykoi cats.

This review discusses recent advances in hair follicle research, highlighting therapeutic and cosmetic applications, but reports no new study results.

This study found that γδ T cells play a role in regulating stromal behavior, influencing the composition and vascularity of fibrotic tissues during the foreign body response.

The study emphasizes that telomere shortening is identified as the sole cause of aging among the twelve hallmarks and suggests that increasing telomere and rDNA array length in adult stem cells might effectively reverse aging and extend lifespan.

This commentary highlights that cetirizine, a widely-used antihistamine, remains effective for various emerging allergic conditions, and new formulations and combination therapies may enhance its effectiveness while being generally well-tolerated.

This review explores the role of hyperandrogenism, including adrenal-derived 11-oxygenated androgen, in the development of polycystic ovarian syndrome and discusses potential therapeutic strategies targeting androgen excess, without reporting new clinical results.

This review discusses the interplay between signaling/transcription factor-mediated and epigenetic mechanisms in skin development and regeneration, highlighting the need for further exploration of epigenome reorganization in these processes.

This study found that the highest rebound value in concrete with high volume slag occurs with 40% slag content, 10–20 mm basalt aggregates, and greater carbonation depth.

This review summarizes the cell type distribution and functional significance of human keratins, emphasizing their roles in tumor diagnosis and potential clinical applications, and reports no new clinical findings.

This review discusses the role of keratins in epithelial cell stress protection and cancer, highlighting their potential as multifunctional regulators and diagnostic markers, without presenting new research findings.

Keratins are crucial for cell structure, growth, and disease risk.

This article discusses the influence of estrogens on hair follicle growth and metabolism, suggesting a significant role alongside androgens in hair growth control but reports no new clinical results.

This review highlights various methods of stem cell communication that reflect the unique organization and function of different tissues and reports no new results.

This study observed specific expression patterns of three zebrafish estrogen receptor genes during development, highlighting robust co-expression of esr2a and esr2b in primary neuromasts, branchial arches, and other tissues.

This review discusses the role of keratins in maintaining epidermal structure and function and reports no new results; the authors emphasize the lack of rational therapies for skin disorders linked to keratin mutations.

This review discusses the influence of oestrogens on various skin components and highlights their modulatory roles and receptor pathways, but it reports no new clinical results.

In this study, expressing human K16 in the epidermis of K14 null mice prevented early skin blistering but led to age-related anomalies, indicating K16 and K14 have distinct roles despite their sequence similarity.

This review discusses the role of estrogens in hair follicle cycling and the skin, highlighting the need for more research on estrogen signaling pathways and their interactions with other factors in hair biology.

This study found that transgenic mice expressing human keratin K8 in the epidermis showed increased progression of skin lesions toward malignancy, suggesting a role for K8 in the development of invasive skin cancer.

This study found that serine 44 in the N-terminal head domain of keratin 17 is phosphorylated in response to various stimuli affecting skin keratinocyte growth, linking K17 up-regulation with growth and stress responses in skin epithelium.