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Sex and race affect immune responses and treatment outcomes in Hidradenitis suppurativa.

This study found that epidermal growth factor receptor inhibitors used in cancer treatment induce a distinct inflammatory response in hair follicles, marked by immune privilege collapse and upregulation of inflammatory pathways.

This study found that Wnt5a expression may suppress cell differentiation and induce an inflammatory response in HaCaT keratinocytes, which could be relevant to psoriasis development.

Alopecia areata is an autoimmune disorder causing hair loss, linked to specific hair follicle antigens and genetic factors.

This study found that patients with telogen effluvium had a higher rate of acute hair loss and lower monocyte counts if they had contracted COVID-19 prior to hair loss onset.

This study found that mice lacking both vitamin D and calcium-sensing receptors in epidermal keratinocytes are predisposed to developing squamous cell carcinoma as they age, due to impaired oxidative stress response and reduced DNA repair capabilities.

This study found that treatment with EGFR inhibitors or mitogen-activated kinase inhibitors may compromise the immune privilege of human scalp hair follicles, suggesting new directions for managing drug-induced folliculitis.

This article reviews sebaceous immunobiology and highlights the complex role of sebaceous glands and sebocytes in skin barrier function and inflammation, particularly in acne pathogenesis, but reports no new results.

This study found that patients with alopecia areata exhibited increased CRHR1 expression on circulating monocytes compared to controls, suggesting that stress-related factors like CRH and CRHR1 may contribute to the development and progression of the condition, particularly in chronic cases and those with larger lesions.

The researchers reported that sulfated chitosan-containing sponges can modulate macrophage activity in diabetic wounds, reducing inflammation and promoting angiogenesis and tissue regeneration, which may enhance wound healing outcomes.

This study suggests that human skin locally synthesizes active sex steroid hormones, impacting inflammation, cell behavior, and wound healing, with potential implications for therapies in aging and impaired wound recovery.

TAK-279 effectively reduces psoriasis symptoms and is safe.

CGF-PF may improve hair loss treatment by targeting hair follicle stem cells more effectively.

In this study, PBMCs from women with PCOS showed reduced TNF-α production over time, potentially limiting their antitumor response to breast cancer cell lines compared to healthy controls.

This study found that in vitro, EGCG may help treat colorectal cancer by targeting iron chelation and the ER stress pathway, leading to apoptosis in cancer cells while sparing normal cells.

This study found that Flammulina velutipes polysaccharides-derived scaffolds greatly enhanced wound healing and hair follicle regeneration in a rat model, particularly with the FPS/NaOH variant showing the best results.

The study found that reducing testosterone in male mice through castration or androgen antagonism significantly accelerated wound healing by decreasing inflammation, suggesting a potential therapeutic target for impaired healing in elderly men.

This study found that reducing testosterone levels in male mice accelerates wound healing and decreases inflammation, suggesting a potential therapeutic target for improving wound repair in elderly males.

This study suggests that dietary grape powder may reduce the severity of atopic dermatitis in a mouse model, highlighting its potential in both prevention and intervention settings.

This review summarizes recent findings on how Wnt signaling proteins play crucial roles in the cutaneous wound healing process but reports no new clinical results.

Mammalian organs regenerate using stem cells and cell plasticity, but this ability declines with age.

This review discusses the differences in wound healing between fetal and adult skin, highlighting the potential to uncover genes for scarless repair that could improve adult wound healing.

This article explores how extrafollicular environments and stem cell configurations influence hair and feather regeneration but provides no new experimental results.

This study found that a specific mutation in the mouse RXRalpha gene significantly impacts immune responses and causes hair loss and skin cysts.

The researchers reported that stress-induced keratins in human skin are expressed at lower levels than those in healthy skin and are co-regulated with genes involved in differentiation, inflammation, and immunity, rather than replacing keratins of normal differentiation or indicating cell proliferation.

SACUMAN, a rare condition causing hair loss without clear signs, is often misdiagnosed and needs scalp biopsies for accurate detection.

This study demonstrated that an AR-EGFP transgene can restore AR function and fertility in Sertoli cell-specific AR knockout mice, highlighting its potential use in understanding androgen receptor functions.

This study found that ingenol mebutate treatment led to gene expression changes in actinic keratoses, with complete lesion clearance in 40% of patients and identified genetic markers potentially predicting treatment response.

This review discusses the complex interplay of factors controlling hair regeneration and highlights the potential for targeted clinical applications in various hair disorders, while reporting no new clinical results.

This study found that RANKL signaling enhances CD8+ T cell-mediated anti-viral immunity during herpes simplex virus infection by preventing apoptosis of Langerhans cells, suggesting potential therapeutic applications.