Deletion of Vitamin D Receptor and Calcium-Sensing Receptor in Keratinocytes Promotes Epidermal Tumorigenesis by Limiting DNA Repair and Oxidative Stress Response Genes

    Yuko Oda, Mark B. Meyer, Iwei Yeh … Daniel D. Bikle
    Studysummary This study found that mice lacking both vitamin D and calcium-sensing receptors in epidermal keratinocytes are predisposed to developing squamous cell carcinoma as they age, due to impaired oxidative stress response and reduced DNA repair capabilities.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on sciencedirect.com →
    Discuss this study in the Community →

    Research cited in this study 4

    1. The Vitamin D Receptor as Tumor Suppressor in Skin Advances in experimental medicine and biology · 2020
    2. Combined Deletion of the Vitamin D Receptor and Calcium-Sensing Receptor Delays Wound Re-Epithelialization Endocrinology · 2017
    3. Overexpression of Hedgehog Signaling Is Associated With Epidermal Tumor Formation in Vitamin D Receptor-Null Mice Journal of Investigative Dermatology · 2011
    4. Inactivation of the Vitamin D Receptor Enhances Susceptibility of Murine Skin to UV-Induced Tumorigenesis ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2008