Deletion of Vitamin D Receptor and Calcium-Sensing Receptor in Keratinocytes Promotes Epidermal Tumorigenesis by Limiting DNA Repair and Oxidative Stress Response Genes
March 2026
in “
The Journal of Steroid Biochemistry and Molecular Biology
”
Studysummary This study found that mice lacking both vitamin D and calcium-sensing receptors in epidermal keratinocytes are predisposed to developing squamous cell carcinoma as they age, due to impaired oxidative stress response and reduced DNA repair capabilities.
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