BI02 (P97): Epidermal Growth Factor Receptor Inhibitor Therapy Induces a Distinct Inflammatory Hair Follicle Response That Includes a Collapse of Immune Privilege
July 2022
in “
British Journal of Dermatology
”
epidermal growth factor receptor inhibitors EGFRi hair follicles folliculitis immune privilege CD4+ cells CD8+ cells CD68+ cells neutrophils mast cells MHC molecules transforming growth factor-β Th1 pathway Th2 pathway T-cell receptor signaling IL-33 EGFR inhibitors immune privilege collapse TGF-beta interleukin-33
Studysummary This study found that epidermal growth factor receptor inhibitors used in cancer treatment induce a distinct inflammatory response in hair follicles, marked by immune privilege collapse and upregulation of inflammatory pathways.
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