LB922 CyTOF Immune Profiling Uncovers Sex- and Race-Specific Differences and Cellular Biomarkers for Biologic Response in Hidradenitis Suppurativa

This study on Hidradenitis suppurativa (HS) involved 74 patients and used CyTOF analysis to explore immune differences across sex and race, as well as potential biomarkers for treatment response. The cohort was predominantly female (81%) and included 50% Black and 41% white participants. Key findings revealed that females had higher levels of certain B and T cells compared to males, while Black individuals had elevated plasmablasts and monocytes but lower basophils and Th1 cells compared to non-Blacks. Patients with more severe disease (Hurley stage 3) showed increased Th17 and Treg cells. Those who failed adalimumab treatment had a higher Th17:Treg ratio, suggesting this axis as a potential biomarker for anti-TNF therapy response. The study underscores the importance of considering demographic factors in HS immune profiling and treatment strategies.