Body Site Heterogeneity and Microbial Diversity Is Lost in Individuals with Hidradenitis Suppurativa
hidradenitis suppurativa skin microbiome axilla groin lesional skin non-lesional skin 16S rRNA gene sequencing β-diversity Cutibacterium Peptoniphilus Porphyromonas Arcanobacterium body site heterogeneity skin niche heterogeneity smoking alcohol use metabolic profiling genetic information processing metabolism environmental information processing bacterial metabolome HS armpit drinking bacterial metabolism
TLDR People with Hidradenitis Suppurativa have less diverse skin bacteria and different bacterial metabolism than healthy individuals.
The study investigated the skin microbiome of the axilla and groin in 11 patients with Hidradenitis Suppurativa (HS) and 10 healthy individuals, focusing on both lesional and non-lesional skin. Using 16S rRNA gene sequencing, it was found that β-diversity was significantly decreased in HS skin compared to normal skin, with notable differences in the relative abundance of specific bacterial genera. Cutibacterium was significantly less abundant in HS skin, while Peptoniphilus and Porphyromonas were more abundant. Arcanobacterium was detected only in HS skin. The study also observed a loss of body site and skin niche heterogeneity in HS patients. Smoking and alcohol use influenced β-diversity in HS skin. Metabolic profiling revealed significant differences in genetic information processing, metabolism, and environmental information processing between normal and HS skin, highlighting the potential role of the bacterial metabolome in HS pathology.
