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This study demonstrates that a 3D-printed agarose microwell platform supports the growth of size-uniform, viable NSCLC cancer spheroids, and can effectively evaluate drug responses using limited tumor material from biopsies, particularly with EGFR tyrosine kinase inhibitors gefitinib and osimertinib.

Increased EGFR gene variations may predict chemotherapy outcomes in small cell lung cancer patients.

In this study, researchers found that using a 5-α reductase inhibitor may reduce inflammation-related cytokines associated with T-helper cell 1 and T-helper cell 2 in prostate tissues after surgery, but it did not affect those related to Th17 cells.

This study found that deleting the Mad2l1 gene in mice leads to rapid onset of acute lymphoblastic leukemia and liver cancer due to induced chromosomal instability.

Isoginkgetin reduces inflammation in cells by blocking NF-κB activation.

This study found that doxorubicin induces hair follicle apoptosis through TRAIL receptor signaling, providing insights for managing chemotherapy-induced hair loss.

This commentary reviews methods for delivering adipose-derived mesenchymal stem cell secretome for facial skin rejuvenation and does not report new clinical results; the authors discuss addressing concerns about administration methods and product characterization.

This article explores how the integrated stress response and senescence-associated secretory phenotype influence stem cell fate decisions, highlighting their dual roles in both protecting and disrupting stem cell integrity.

This in vitro study found sex chromosome differences affect steroidogenic enzyme activity and androgen receptor expression in human skeletal muscle cells, showing varied responses to testosterone exposure between 46XY and 46XX cells.

This review discusses advances in CRISPR/Cas9 variants and nanoformulations for cancer treatment, noting challenges and prospects for clinical application, but reports no new research results.

This review highlights the potential of microneedles for immunotherapy, emphasizing their ability to enhance immune responses and reduce side effects through precise and stimuli-responsive delivery, especially in tumor treatment, while also noting the limitations and areas for improvement in current systems.

Dr. Zitelli emphasized that "Mohs surgery" should only be called that when one doctor does both the surgery and pathology.

This study suggests that increased T cell blastogenesis may predict a positive response to topical 5% minoxidil treatment in patients with severe alopecia areata.

This study found that D-peptide crosslinked MAP hydrogel accelerated material degradation in vivo but significantly enhanced skin regeneration, suggesting an adaptive immune response can drive regenerative healing even with rapid scaffold breakdown.

This review examines the complexities of age-related skin healing and discusses how translating findings from model organisms to humans could enhance understanding and treatment of impaired regeneration in aging populations, but it reports no new clinical results.

In this study, four dogs with a novel skin disease showed clinical lesions involving verrucous, crusted papules and plaques, and responded variably to immunosuppressive therapy, suggesting an immune-mediated cause.

In this study, researchers developed a biocompatible, ROS-responsive hydrogel to deliver miR-665 locally, effectively reducing inflammatory signaling and promoting hair follicle regeneration in an alopecia areata mouse model, offering a promising approach for targeted treatment.

This study found that a newly developed biocompatible hydrogel, responsive to reactive oxygen species, enabled targeted delivery of miR-665, significantly promoting hair regeneration and reducing T-cell infiltration in a mouse model of alopecia areata, suggesting a promising strategy for treating this condition.

In this study, finasteride treatment in men with androgenetic alopecia reduced the expression of caspases in hair follicles to levels similar to those in men with normal scalps.

In this case study, the progression of alopecia universalis in a Japanese man was linked to the involvement of Th1 and Th17 cells, suggesting an autoimmune mechanism.

This review discusses how inflammation influences hair follicle stem cell activities like wound healing and follicle cycling and suggests a potential link between inflammation, stem cell activation, and programmed cell death.

This study found that isolated red light may serve as an alternative for photo-immunotherapy without additional photosensitizers, as it did not reduce keratinocyte differentiation markers or increase photo-oxidative damage, unlike treatment with IL-4 or UVA1/blue light.

The researchers in this study identified molecular mechanisms involved in frontal fibrosis alopecia, highlighting immune response and fatty acid metabolism, and developed a four-gene diagnostic model showing high accuracy in distinguishing affected individuals from controls.

This study found that patterned hair plucking in mice triggers a collective regeneration response in nearby unplucked hair follicles via a quorum sensing mechanism involving immune signaling.

This study discovered that the circadian clock influences hair follicle regeneration, making hair grow faster in the morning and causing more radiation-induced hair loss in the morning compared to the evening.

This study found that low oxygen conditions and ECM degradation products increased the proliferation and migration of perivascular stem cells without altering their phenotype, suggesting potential roles in tissue repair.

This study found distinct gene expression profiles in alopecia areata-affected skin, suggesting T-cell mediated immune responses and unique gene profiles between different stages of the disease.