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Certain SHBG gene variants, like rs727428, are linked to higher testosterone levels in women with PCOS.

Male rats have androgen receptors in their liver, which are different from proteins that bind estrogen.

The conclusion is that removing both ovaries is the best treatment for excess male hormones in postmenopausal women, with medication as another option, and managing insulin resistance is important for diagnosis and treatment.

The enzymes 5α-reductase and 3α/β-hydroxysteroid oxidoreductase help create brain-active substances from progesterone and testosterone, which could be used for treatment, but more research is needed to ensure their safety and effectiveness.

Quercetin-loaded nanoparticles can penetrate skin, minimize hair loss, and promote hair regrowth, showing slightly better results than a marketed product.

The document concludes that PCOS has a strong genetic component, but more research is needed to fully understand the specific genes involved.

Researchers used CRISPR/Cas9 to create a goat with a gene that increased cashmere production by 74.5% without affecting quality.

The document concludes that low-dose oral contraceptives and hormonal therapies can manage perimenopause symptoms and reduce some health risks, but lifestyle changes and disease screening are also important.

The estradiol valerate/dienogest oral contraceptive helps with heavy periods, may improve acne and symptoms in PCOS, and doesn't affect sexual function.

The study suggests certain ACE gene variations are more common in women with PCOS and may be linked to increased insulin resistance.

Some hair loss and prostate drugs might increase the risk of diabetes and heart disease.

The document concludes that hormonal biomarkers are key for diagnosing hyperandrogenemia in women and hypogonadism in men.

Women with polycystic ovary syndrome have a higher risk of certain fractures.

Overweight women with PCOS have higher levels of certain hormones that could indicate a higher risk of heart and metabolic problems.

Obese Hispanic women with PCOS are at higher risk for metabolic problems than non-Hispanic white women.

Higher Lnk protein levels in ovaries may lead to insulin resistance in women with PCOS.

Androgens can both increase body hair and cause scalp hair loss.

Testosterone and dihydrotestosterone have similar effects on body composition and metabolic health in men.

Proscar (finasteride) blocks 5α-reductase in sea urchin ovaries and testes, suggesting potential treatment for androgen-related conditions.

Cyproterone acetate is the preferred treatment for women's hyperandrogenism when estrogen/progestogen use is safe.

Blood removal and birth control pills both helped with hormone levels in women with PCOS, but birth control was better for regular periods and blood removal had fewer side effects.

Certain gene variations might help protect against insulin resistance and glucose intolerance in people with Polycystic Ovary Syndrome.

A patient with Werner syndrome showed a range of aging-like symptoms and metabolic issues, underscoring the need for early detection and treatment.

The proteins transthyretin and megalin are more present in the growth phase of hair, suggesting they might affect hair health and growth.

Healthcare providers should start with simple fertility tests and treatments before referring patients to specialists.

The right dosage of CPA and TB can work as a safe and reversible male contraceptive in monkeys.

Lymphatic vessels are essential for health and can be targeted to treat various diseases.

Menopause often leads to lower sexual desire and discomfort during sex, but treatment should be personalized and only if it bothers the woman.

Finasteride effectively treats hair loss and enlarged prostate in men, with mild side effects.

The document concludes that hirsutism can be managed with various treatments tailored to the individual, potentially improving quality of life.