Improvement of Endothelial Function with Metformin and Rosiglitazone Treatment in Women with Polycystic Ovary Syndrome

July 2008 in “ European journal of endocrinology ”

Mojca Jensterle, Miran Šebeštjen, Andrej Janez, Janez Prezelj, Tomaz Kocjan, Irena Keber, Marija Pfeifer

metformin rosiglitazone polycystic ovary syndrome insulin resistance testosterone endothelial function flow-mediated dilation brachial artery menstrual bleeding frequency MET ROSI PCOS FMD

TLDR Metformin and rosiglitazone improve blood vessel function in women with PCOS, with metformin also reducing insulin resistance and testosterone levels.

In the 2008 study involving 26 women with polycystic ovary syndrome (PCOS), metformin (MET) and rosiglitazone (ROSI) treatments over 6 months were found to significantly improve endothelial function, as indicated by increased flow-mediated dilation (FMD) of the brachial artery. MET treatment also resulted in a significant decrease in insulin resistance, serum total and free testosterone levels, and an increase in menstrual bleeding frequency. The study concluded that MET and ROSI could markedly improve endothelial function in young PCOS patients, potentially reversing early-stage atherosclerotic processes, with MET providing additional benefits in reducing insulin resistance and testosterone levels.

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