This review discusses various techniques for depigmentation in vitiligo patients and suggests that cryotherapy, performed by an experienced professional, may be the most cost-effective and accessible method.
1 citations
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January 2023 in “Research Square (Research Square)” In this report, a 61-year-old woman with vitiligo showed significant improvement after tofacitinib treatment but developed lung adenocarcinoma, highlighting potential cancer risks associated with JAK inhibitors.
6 citations
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January 2007 in “Actas dermo-sifiliográficas/Actas dermo-sifiliográficas” This study found that topical application of triiodothyronine (T3) can induce the transition of hair follicles from the telogen to the anagen phase in mice and stimulate hair shaft growth in vitro.
11 citations
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September 2024 in “Journal of the European Academy of Dermatology and Venereology” This review explores the shared pathogenesis of alopecia areata and vitiligo and compares treatment responses, noting that hair regrowth in alopecia areata occurs more rapidly than skin re-pigmentation in vitiligo, possibly due to differences in stem cell biology and treatment effects on melanocytes.
June 2023 in “Clinical Cosmetic and Investigational Dermatology” In this study, a combined technique of mini-punch grafting and follicular hair transplant was used on five patients with stable hairline vitiligo, resulting in satisfactory repigmentation and hair regrowth within the hairline while preventing hair loss and achieving repigmentation outside it.
October 2010 in “eCommons (Cornell University)” This case report highlights that cutaneous epitheliotropic lymphoma in dogs can present with various skin lesions, such as depigmentation, making diagnosis challenging for veterinarians.
18 citations
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October 2022 in “Biomedicines” This review presents clinical and preclinical evidence supporting innovative regenerative approaches to treat vitiligo, as existing treatments lack a specific cure and predictable long-term repigmentation outcomes.
2 citations
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January 2023 in “International journal of biological sciences” This review discusses the mechanisms of hair repigmentation and reports no clinical results; the authors suggest further research into topical treatments for reversing gray hair.
April 2018 in “Dermatologic Surgery” A new surgical technique using vellus hair grafts effectively treated vitiligo without causing unwanted hair growth.
1 citations
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December 2023 in “Skin Research and Technology” This study reported successful repigmentation of perioral vitiligo using upper hair follicle transplantation combined with a 308 nm excimer laser, without undesirable hair growth in the treated areas, offering a potential approach for treating vitiligo cases unresponsive to traditional melanocyte transplantation.
May 2025 in “International Journal of Trichology” In this case report, a 60-year-old man with rheumatoid arthritis and sudden hair whitening was treated with baricitinib, showing significant hair repigmentation and regrowth in 8 months, suggesting potential for baricitinib in managing canities subita, especially when linked to alopecia areata.
8 citations
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July 2001 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology” This review summarizes the historical and evolving treatments for vitiligo, highlighting that combining medical and surgical approaches may enhance repigmentation outcomes, though more research and new protocols are needed.
June 2024 in “Stem cell research & therapy” This systematic review examined 64 randomized controlled clinical trials on regenerative medicine for specific dermatologic disorders, reporting up to 68.4% improvement in androgenetic alopecia and up to 71% improvement in vitiligo among 2888 patients.
14 citations
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July 1977 in “PubMed” This study reported that a 19-year-old man's essential fatty acid deficiency was reversed with daily topical application of linoleic acid, improving clinical symptoms and normalizing certain fatty acid levels.
10 citations
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January 2010 in “Acta dermato-venereologica” Light therapy can effectively treat vitiligo and hair loss caused by a specific medication.
8 citations
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March 2017 in “Journal of Cosmetic and Laser Therapy” In this study, researchers found that punch grafting was more effective than follicular hair transplantation for treating stable vitiligo; however, follicular hair transplantation was found to be cosmetically preferable for exposed areas like the face due to fewer side effects.
2 citations
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May 2023 in “Photobiomodulation, photomedicine, and laser surgery” This editorial reviews how photobiomodulation therapy might effectively treat both hyperpigmentation and depigmentation skin disorders, but reports no new clinical results.
69 citations
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April 1998 in “Journal of The American Academy of Dermatology” In this study, single hair grafting was reported to be an effective treatment for localized/segmental vitiligo, notably in hairy skin areas, with repigmentation observed in 82% of those cases.
26 citations
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February 2011 in “Journal of Plastic Reconstructive and Aesthetic Surgery” Technique effectively treats deformities, achieves re-pigmentation, and releases scar contractures.
January 2026 in “Indian Journal of Plastic Surgery” This study evaluated nonculture epidermal suspension for stable vitiligo and found it to be effective, with 68% mean repigmentation and 43.1% of patients achieving excellent results; it showed sustained benefits over long-term follow-up and was generally safe with minor adverse events in 13.7% of participants.
May 2022 in “Dermatologic therapy” Combining PRP with follicular transplantation improves vitiligo treatment better than follicular transplantation alone.
March 2017 in “Current dermatology reports” Topical JAK inhibitors can effectively treat alopecia areata and vitiligo by modulating immune responses.
1 citations
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July 2024 in “Journal of Investigative Dermatology” VYN201 shows promise as a safe and effective treatment for non-segmental vitiligo.
14 citations
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July 1977 in “Archives of Dermatology” This case report found that a linoleic acid topical application reversed essential fatty acid deficiency and improved scalp dermatitis, alopecia, and hair depigmentation in a 19-year-old patient on fat-free intravenous nutrition.
2 citations
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May 2025 in “IntechOpen eBooks” This article highlights that early and high-dose corticosteroid therapy, along with immunosuppressive agents, is crucial for managing Vogt-Koyanagi-Harada disease, and emerging biological therapies may benefit refractory cases.
4 citations
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October 2020 in “JAAD Case Reports” This article discusses the potential use of platelet-rich plasma as a treatment for vitiligo, but reports no new clinical results; further investigation is needed.
3 citations
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June 2025 in “Stem Cell Research & Therapy” Hair follicle-derived melanocyte transplant could effectively treat vitiligo by restoring skin color.
2 citations
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June 2024 in “Archives of Dermatological Research” In this study, researchers compared three treatments for stable vitiligo and found that a combination of follicular cell suspension and mini punch grafting resulted in significantly better re-pigmentation after six months compared to using either method alone.
June 2026 in “Journal of Investigative Dermatology” This study found that certain proteins linked to immune suppression and melanogenesis are associated with repigmentation in vitiligo patients undergoing standard treatment, suggesting these proteins and their pathways play roles distinct from merely reversing skin lesions.
December 2024 in “Cureus” This case study reports a young male with alopecia universalis experienced significant hair whitening following baricitinib treatment, highlighting the need for further research on JAK inhibitors' impact on hair pigmentation and their underlying mechanisms.