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Glossary Pigmentation Changes

alterations in skin, hair, or eye color due to melanin variations

Pigmentation changes refer to alterations in the color of the skin, hair, or eyes due to variations in melanin production. These changes can manifest as hyperpigmentation (darkening) or hypopigmentation (lightening) and may result from factors such as sun exposure, hormonal changes, medical conditions, or certain medications. Understanding these changes is crucial for diagnosing and treating various dermatological conditions.

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Research

5 / 1000+ results

research Hair cycle and hair pigmentation: dynamic interactions and changes associated with aging

152 citations , December 2003 in “Micron”

This review discusses the development, regulation, and aging of the human hair follicle pigmentary system and suggests potential for reversing hair graying by manipulating follicle melanocytes in vitro, but reports no clinical results.

research 458 UVB-induced facultative pigmentation is associated with distinct DNA methylation changes

November 2025 in “Journal of Investigative Dermatology”

This study found that UVB exposure led to visible tanning and distinct DNA methylation changes in pigmentation genes in tan-capable skin but not in non-tan skin, highlighting GNAS as a potentially UVB-responsive gene.

research Grey hair: clinical investigation into changes in hair fibres with loss of pigmentation in a photoprotected population

17 citations , February 2011 in “International Journal of Cosmetic Science”

This study found that individual differences between pigmented and unpigmented hair fibers in Old Order Mennonites suggest grey hair may be perceived as drier and less manageable due to small mechanical and moisture changes.

research Cutaneous changes in patients with chronic renal failure on hemodialysis

17 citations , February 2012 in “Cutaneous and Ocular Toxicology”

This study found that xerosis and pruritus are prevalent in patients with chronic renal failure undergoing hemodialysis, highlighting the importance of early recognition of skin issues to alleviate discomfort and reduce complications.

Pigmentation and Pregnancy: A Study on Skin Changes

research Pigmentation and Pregnancy

15 citations , December 2016 in “Obstetrics & Gynecology”

This review discusses the effects of pregnancy on melanocytic nevi and reports no new clinical results; it suggests that changing nevi during pregnancy should be evaluated similarly to those in nonpregnant patients.

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Learn

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learn Scalp Micropigmentation

Does scalp micropigmentation change color over time? SMP pigments may gradually lighten over time but are designed to maintain a natural tone.
Does scalp micropigmentation fade over time? Scalp micropigmentation typically fades over time and requires periodic touch-ups.
Can scalp micropigmentation be removed? Scalp micropigmentation can be removed using laser treatments, but results may vary.
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learn Hair Multiplication

extract, clone, and reinsert your own hair cells

learn Overview

learn Stem Cell Factor

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Community Join

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community 1.5 years on fin - 1.25mg daily

in Progress Pictures 27 upvotes 1 month ago

The user has been taking finasteride 1.25mg daily since February 2025, with no noticeable side effects and occasional use of keto shampoo. The treatment seems to have stabilized hair loss, with some users noting subtle regrowth and pigmentation changes.

community Just received my 2 Deoxy D Ribose wish me luck🫡

245 upvotes 2 years ago

A user is trying 2-deoxy-D-ribose with distilled water for hair growth, observing new hair and skin pigmentation changes. Others compare it to Minoxidil, expressing interest and caution about its effectiveness and safety.

community Rosemary Oil experiment 4 months in

in Research/Science 46 upvotes 5 months ago

A user experimented with applying pure rosemary oil to a single hair strand twice daily, observing increased thickness and pigmentation, but questioned if the oil or the application method caused the change. Some users noted rosemary oil might be as effective as 2% minoxidil for hair growth, though others warned about potential harm from using undiluted oil.

community John Cena Says Hair Transplant 'Changed The Course Of My Life' and maintains with daily routine that includes "red-light therapy, minoxidil, vitamins, shampoo"

in Transplants 2620 upvotes 1 year ago

John Cena attributes his improved life and career to a hair transplant and maintenance routine with red-light therapy, minoxidil, vitamins, and shampoo. Users discuss the effectiveness and side effects of finasteride, with mixed opinions on its necessity.

community White hair seemed to be turn black, re-pigmentation

1 upvotes 10 months ago

The user experienced hair repigmentation and attributes improvements in hair and overall health to a carnivore diet, Boron, and Selenium supplementation. They stopped using finasteride after 20 years, noticed increased testosterone and libido, and observed hair regrowth with RU58841.

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Clinics

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