152 citations
,
December 2003 in “Micron” This review discusses the development, regulation, and aging of the human hair follicle pigmentary system and suggests potential for reversing hair graying by manipulating follicle melanocytes in vitro, but reports no clinical results.
November 2025 in “Journal of Investigative Dermatology” This study found that UVB exposure led to visible tanning and distinct DNA methylation changes in pigmentation genes in tan-capable skin but not in non-tan skin, highlighting GNAS as a potentially UVB-responsive gene.
17 citations
,
February 2011 in “International Journal of Cosmetic Science” This study found that individual differences between pigmented and unpigmented hair fibers in Old Order Mennonites suggest grey hair may be perceived as drier and less manageable due to small mechanical and moisture changes.
17 citations
,
February 2012 in “Cutaneous and Ocular Toxicology” This study found that xerosis and pruritus are prevalent in patients with chronic renal failure undergoing hemodialysis, highlighting the importance of early recognition of skin issues to alleviate discomfort and reduce complications.
15 citations
,
December 2016 in “Obstetrics & Gynecology” This review discusses the effects of pregnancy on melanocytic nevi and reports no new clinical results; it suggests that changing nevi during pregnancy should be evaluated similarly to those in nonpregnant patients.
96 citations
,
January 1997 in “Clinics in Dermatology” This study found that G protein-coupled estrogen receptor enhances melanin synthesis in melanoma cells through cAMP-PKA-MITF-TYR signaling, suggesting its potential as a drug target for chloasma treatment.
6 citations
,
January 1967 in “Journal of Small Animal Practice” This study observed that aged dogs exhibit atrophy of the epidermis, appendages, and dermis, along with variable skin changes and increased dermal pigmentation, but lack senile elastosis seen in humans.
March 2026 in “International Journal of Health Science” In this narrative literature review, researchers found that physiological skin changes are extremely common during pregnancy due to hormonal and circulatory adaptations, emphasizing the need for healthcare professionals to recognize these changes to provide proper guidance to pregnant women and avoid unnecessary interventions.
February 2025 in “The Open Dermatology Journal” In this study conducted at Afzalipour Hospital in Iran, researchers found a significant prevalence of alopecia, particularly resembling telogen effluvium, among COVID-19-recovered patients, with hair loss being more common in females and correlating with arterial oxygen saturation levels.
18 citations
,
January 2020 in “Ecology and evolution” This study analyzed gene expression changes during the autumn coat color change in mountain hares and found conserved gene regulation with snowshoe hares, highlighting its role in seasonal camouflage adaptation.
1 citations
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December 2019 in “Clinical ophthalmology” This study found that bimatoprost eye drops increased eyelash length, thickness, pigmentation, and the number of eyelashes per follicle in rabbits, without causing inflammation.
January 2007 in “Journal of the American Academy of Dermatology” A 73-year-old man's grey-white hair turned dark brown after eczema treatment.
20 citations
,
February 2023 in “Biology” This review highlights the possibility of safely altering hair color through innovative cosmetics by targeting key biological processes in hair follicles, using insights from mammalian pigmentation studies and drug-induced hair color changes as potential pathways.
June 2026 in “Journal of Advances in Biology & Biotechnology” In this study conducted at the Veterinary Clinical Complex in Bikaner, Rajasthan, researchers found that among 240 canine dermatitis cases, 25 dogs had demodicosis, characterized by various hematological and serum biochemical changes, and distinctive histopathological alterations in skin samples.
26 citations
,
September 1969 in “The American journal of medicine” This article reviews Cronkhite-Canada syndrome as a distinct condition from Peutz-Jeghers syndrome and familial polyposis, with cases showing gastrointestinal polyposis, skin, hair, nail abnormalities, and hypoproteinemia.
August 2026 in “Women s Health” This preliminary pilot study found that a combined microneedling-assisted Panax ginseng exosome protocol with adjunctive inner gel use led to short-term improvements in patient-reported vulvovaginal symptoms and qualitative improvements in vulvar skin tone, though results are preliminary and based on a small, uncontrolled sample.
78 citations
,
September 2008 in “International Journal of Cosmetic Science” This review outlines various clinical methods for assessing ageing skin and discusses their application in supporting the efficacy claims of anti-ageing treatments, but it reports no new clinical results.
73 citations
,
June 2003 in “Journal of the American Academy of Dermatology” This article reviews common hair-care practices among African American patients and discusses how these practices relate to hair and scalp disorders, without presenting new clinical research.
67 citations
,
October 1997 in “Dermatologic Surgery” This study found that the EpiLight Hair Removal System achieved approximately 60% hair removal after 12 weeks following a single treatment, indicating effectiveness and safety for long-term hair reduction.
61 citations
,
October 2010 in “Postgraduate Medical Journal” This study found that dermatological issues, such as xerosis and pigmentation, are common in chronic kidney disease patients and increase with the severity and duration of the disease, indicating that dialysis often exacerbates these conditions.
52 citations
,
February 2012 in “Plastic Surgery International” This review describes techniques for successful skin grafting and variations of the procedure, reporting no new clinical results.
6 citations
,
November 2024 in “Medicine International” In this systematic review, researchers reported that post-COVID-19 syndrome can lead to various dermatological symptoms, including skin rash, alopecia, pruritus, and dermatitis, with a notable prevalence of autoimmune-related skin changes, especially among females and those with severe COVID-19 history.
5 citations
,
April 1984 in “Archives of Dermatology” This article reviews the characteristics, causes, and types of porphyria cutanea tarda but presents no new findings, focusing instead on existing knowledge about the disorder.
5 citations
,
December 1978 in “PubMed” This article reviews the connection between malabsorption syndrome and skin diseases, reporting common skin complications and noting their improvement with malabsorption treatment; it offers no new clinical results.
3 citations
,
February 2025 in “Journal of PHYSIOLOGICAL ANTHROPOLOGY” This systematic review and meta-analysis found 30 genetic loci associated with skin ageing phenotypes, noting shared biological pathways in aspects like pigmentation and wrinkling; researchers suggest further studies targeting the same SNP across populations could clarify these associations.
2 citations
,
October 2024 in “Journal of Cosmetic Dermatology” This study highlights that chemicals used in brow lamination, like ammonium thioglycolate and thioglycolic acid, may cause skin irritation and other systemic issues, suggesting a need for further investigation and regulatory measures.
1 citations
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January 2009 in “Elsevier eBooks” This review discusses the mechanisms of laser and IPL hair removal, particularly for darker skin types, and reports no new findings, highlighting potential adverse effects like pigmentation changes or scarring with improper use.
August 2026 in “Zenodo (CERN European Organization for Nuclear Research)” This paper proposes an integrated model suggesting that psychological stress, sleep disturbances, nutrition, lifestyle, and various biological factors collectively influence hair health, including hair loss and premature greying.
August 2026 in “Zenodo (CERN European Organization for Nuclear Research)” This study synthesizes evidence on the complex interplay between stress, sleep, nutrition, lifestyle, and systemic health and their impact on hair health, encompassing premature greying, hair loss, and follicle cycling.
June 2026 in “IECCMEXICO” This review found that dermatological manifestations often indicate systemic diseases, with endocrine-metabolic disorders, autoimmune diseases, and renal or hepatic conditions frequently linked to specific skin changes, highlighting the diagnostic importance of skin examination in internal medicine and endocrinology.