This study found that lentivirus-mediated overexpression of Sonic hedgehog significantly increased hair follicle stem cell proliferation and promoted hair follicle regeneration, with higher effects in non-alopecia areas.
March 2020 in “Central European Journal of Biology” This study found that isolated hair follicle outer root sheaths from mice can regenerate new dermal papillary structures in vitro, with stem cells and neutrophils playing key roles in the regeneration process.
12 citations
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November 2012 in “Bulletin of experimental biology and medicine” Taxifolin-based treatments help skin heal after chemical burns.
3 citations
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March 2013 in “PubMed” This study found that applying 10% platelet-rich plasma significantly increased hair follicle density and reduced the time for hair formation in a mouse model compared to no PRP treatment.
February 2013 in “Seoul National University Open Repository (Seoul National University)” Ameloblasts and odontoblasts help hair follicles regenerate.
February 2019 in “Chin J Injury Repair and Wound Healing(Electronic Edition)” This study indicates that porcine acellular dermal matrix may aid hair follicle regeneration in mice by enhancing the expression of SDF-1 and the Wnt3a/β-catenin signaling pathway.
84 citations
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January 2018 in “Biomaterials Science” Sericin hydrogels heal skin wounds well, regrowing hair and glands with less scarring.
8 citations
,
February 2017 in “International journal of molecular sciences” This study found that the natural extract e-CAF promotes the proliferation and migration of human hair dermal papilla cells in vitro, suggesting potential benefits for skin regeneration and tissue repair.
3 citations
,
June 2021 in “PLOS ONE” This study found that topical application of the BRAF inhibitor vemurafenib improved wound healing and promoted hair follicle regeneration in a diabetic murine model.
39 citations
,
August 2022 in “Cell Death and Disease” This study found that a dopamine-methacrylated hyaluronic acid hydrogel enhances the efficacy of adipose-derived stem cells in promoting skin regeneration, potentially involving the Notch signaling pathway.
25 citations
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February 2024 in “Biomaterials” In this study, iPSC-derived epidermal organoids demonstrated potential as a novel tool for regenerative medicine by producing high-performance extracellular vesicles that promote proliferation, migration, and angiogenesis in cell-free therapies for wound healing.
6 citations
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December 2022 in “Biomedicines” This study found that the expression of the sonic hedgehog protein is involved in wound healing texture regeneration, inhibiting skin texture after embryonic day 14 and affecting keratinocyte migration and division.
April 2018 in “Radiotherapy and Oncology” Prostaglandin helps regenerate hair follicles after radiation damage.
October 2025 in “Journal of Molecular Structure” Hyaluronic acid microneedles help deliver minoxidil derivatives effectively for hair regrowth.
3 citations
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June 2017 in “International Journal of Radiation Biology” This review of murine studies reports that γ-rays affect hair follicle pigmentation in mice throughout the hair cycle, while effects on hair structure may be obscured by aging.
2 citations
,
November 2025 in “Biomedicines” This review explores how platelet- and marrow-derived biologics like PRP and BMAC exhibit both regenerative and antimicrobial properties useful in musculoskeletal conditions and wound healing, though their clinical outcomes are affected by preparation inconsistencies and lack of standardized protocols.
June 2025 in “Problems of Cryobiology and Cryomedicine” In this study, the researchers found that tyndallization effectively sterilizes aqueous solutions of hyaluronic acid without diminishing their regenerative properties, and these properties remain intact even at low temperatures, supporting potential applications in cryobiology and cryomedicine.
78 citations
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October 2012 in “Biomaterials” This study found that both human and rat dermal papilla spheroids can induce hair follicle neogenesis, but larger spheroids increase inductivity without significantly affecting hair fiber diameter.
8 citations
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May 2021 in “Applied Materials Today” This study found that Cur-Fe-mesoporous silica nanoparticles synergistically inhibited scar formation and promoted hair follicle regeneration in skin burn wound healing by releasing bioactive components like SiO32−, Fe3+, and Fe-Cur chelates.
2 citations
,
January 2020 in “Libri Oncologici Croatian Journal of Oncology” In this study, PRP injections into the muscular layer of rabbits' intestinal walls improved anastomosis regeneration with less adhesion compared to PRP soaking, though further research is needed to determine the best application method.
1 citations
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December 2019 in “Archives of the Balkan Medical Union” In this study, injecting platelet-rich plasma into the muscular layer of the intestinal wall in rabbits significantly reduced adhesion development compared to soaking methods, suggesting an improvement in anastomosis regeneration.
November 1971 in “Bulletin of Experimental Biology and Medicine” The location of a skin injury affects how well a rat's skin can heal.
4 citations
,
December 2015 in “Journal of Medicinal Plants Research” This study reports that a 30% ethanol extract of a plant mixture enhanced hair growth in human hair dermal papilla cells and mice, suggesting potential use in hair growth products.
August 2024 in “Bioorganic Chemistry” This study found that oral administration of cedrol, a component of ginger, improved hair regeneration and reduced hair follicle damage in cyclophosphamide-induced alopecia areata in mice more effectively than external administration, by enhancing cytokine expression and modulating key signaling pathways.
February 2020 in “Int J Biologicals” This study found that super-activated platelet lysate increased hair follicle density in a mouse model of androgenetic alopecia, outperforming platelet-rich plasma and platelet lysate.
269 citations
,
October 2017 in “International Journal of Molecular Sciences” This review examines the challenges of cell engraftment in regenerative medicine and discusses potential strategies to improve the efficacy of cell-based therapies, including cell-free regenerative approaches.
4 citations
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December 2017 in “International Journal of Biomedicine” In this study, the introduction of autofibroblasts into ischemic wounds was found to be slightly less favorable for regenerative histogenesis compared to a dermal equivalent with heterofibroblasts, with minor differences in epidermis thickness, collagen fiber area, and blood vessel area.
This study found that epidermal growth factor promotes hair cell regeneration in young chickens damaged by gentamicin, accelerating recovery to normal basilar papilla structure.
February 2024 in “Cosmetics” The correction fixes an image mistake in the original publication, but the findings on the hair treatment's effectiveness are unchanged.
35 citations
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July 2018 in “Cell Reports” This study found that the dermal papilla of the hair follicle regulates stem cell quiescence and regeneration by modulating Shh and Wnt signaling pathways, highlighting the importance of signaling cross talk in regeneration.