Preparation of Super-Activated Platelet Lysate and Its Effect on Hair Follicle Regeneration in a Mouse Model of Androgenetic Alopecia

February 2020 in “ Int J Biologicals ”

Chun-Xiang Liu, Bohao Wang

super-activated platelet lysate sPL hair follicle regeneration androgenetic alopecia ultrafiltration centrifugation freeze-thaw methods platelet-rich plasma PRP platelet lysate PL

TLDR Super-activated platelet lysate significantly promotes hair regrowth in mice with androgenetic alopecia.

The study aimed to prepare super-activated platelet lysate (sPL) and investigate its effect on hair follicle regeneration in a mouse model of androgenetic alopecia (AGA). Using ultrafiltration centrifugation and freeze-thaw methods, sPL was obtained from platelet-rich plasma (PRP). The sPL contained significantly higher levels of hair follicle regeneration-related factors compared to PRP and platelet lysate (PL). Treatment with sPL led to noticeable hair regrowth and restoration of hair follicle density to control levels in AGA mice. The results suggested that sPL had a significant effect on hair follicle regeneration, making it a promising candidate for AGA treatment.

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