Effect of Different Concentrations of EGF on the Culture of Goat Hair Follicle Stem Cells

January 2009

Shi Mingyan, Feng Lin, Xueyi Yang, Dou Zhongying

epidermal growth factor hair follicle stem cells EGF

TLDR EGF helps goat hair stem cells grow best at 15 ng/mL.

The study investigated the effect of different concentrations of EGF on goat hair follicle stem cells cultured in vitro. Hair follicles were isolated and treated with various concentrations of EGF (0, 10, 15, 20 ng/mL). The results indicated that EGF positively influenced the growth of these stem cells, with the optimal concentration being 15 ng/mL.

Discuss this study in the Community →

Related Community Posts Join

6 / 80 results

community New and Interesting HairLoss Studies/Papers/Reviews

in Treatment 42 upvotes 5 years ago

Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.

Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

in Research 865 upvotes 1 year ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

community The end of balding: We may have just found the secret to hair regrowth

in Technology 676 upvotes 6 months ago

MCL-1 is important for hair follicle stem cell survival, but its impact on human hair regrowth is unclear. Minoxidil and finasteride are the main treatments, with doubts about new discoveries leading to effective human solutions soon.

community The Real Cause Of Androgenetic Alopecia

in Research/Science 679 upvotes 1 year ago

Androgenetic alopecia is caused by DHT affecting hair growth. Finasteride and minoxidil are used to manage hair loss by blocking DHT and promoting hair growth.

community Clearing the air on how non-surgical treatments really work

16 upvotes 6 years ago

Treatments for hair loss, including finasteride, dutasteride, minoxidil, ketoconazole, microneedling, and low level laser light therapy, which aim to reduce DHT production, increase cell absorption and blood flow, and stimulate epidermal stem cells. It also stresses the importance of patience when using these treatments.

community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 830 upvotes 1 year ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

Related Research

6 / 6 results

research Culture and Characterization of Rat Hair Follicle Stem Cells

2 citations , January 2016

This study successfully established methods for isolating, culturing, expanding, and characterizing rat hair follicle stem cells (rHFSCs) from 1-week-old Sprague-Dawley rats. The rHFSCs were cultured in a specialized medium and purified using adhesion to collagen IV. Characterization through immunofluorescent staining and real-time PCR confirmed the expression of specific marker genes and the absence of keratinocytes. The cells exhibited typical cobblestone morphology, good adhesion, and colony-forming ability, with a notable proliferative capacity, particularly in the logarithmic phase on days 5-6. However, cell vitality decreased from the 7th passage. The study concluded that highly purified rHFSCs with good proliferative capacity could be obtained, making them a promising cell source for tissue-engineered hair follicles, vessels, and skin.

research Experimental Study on the Isolation, In-Vitro Culture, and Relevant Test of Rat Hair Follicle Stem Cells

1 citations , January 2014 in “Chinese Journal of Traditional Medical Traumatology & Orthopedics”

The methods can provide high-quality cells for creating artificial hair follicles, blood vessels, and skin.

research Influences of Different Mediums on Goat Hair Follicles Cultured In Vitro

4 citations , January 2008 in “Journal of Shandong University”

Serum-free mediums with VEGF and EGF boost goat hair follicle growth best.

research Rat hair follicle growth in vitro

58 citations , December 1992 in “British Journal of Dermatology”

research In Vitro Keratin Expression of Hair Cells

2 citations , November 1992 in “Journal of dermatology”

Hair cells grown in a lab showed specific hair proteins.

research [Methods for optimized cultivation of hair cells from C3H mice].

6 citations , October 1989 in “PubMed”

Optimized conditions and specific treatments enhance the growth of hair cells from C3H mice.