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This review discusses recent advances in stimuli-responsive nanoformulations for CRISPR-Cas9 delivery, highlighting their design rationales and potential biomedical applications, but reports no new experimental results.

This research highlights selenium's critical roles in various biological processes and underscores the potential health impacts of both its deficiency and excess, including increased mortality risk, poor immune function, and neurological issues.

This review reports on the potential of non-viral and stimuli-responsive systems to improve CRISPR-Cas9 delivery for gene-editing therapies, highlighting recent progress with systems like lipid-based nanoparticles that enhance targeting specificity and stability.

This study developed a hydrogel microneedle system combining ginseng-derived exosomes and biomimetic nanoparticles to address oxidative stress, inflammation, and melanocyte deficiency in vitiligo, showing significant repigmentation in mice within 3 weeks by enhancing melanocyte protection and keratinocyte proliferation.

This review discusses recent findings on cellular antioxidant responses to oxidative stress and their implications for treating various human diseases but reports no new clinical results.

This review explores the complex relationships between ferroptosis, anastasis, and chemoresistance in cancer therapy, highlighting the potential of combining ferroptosis with immunotherapy to overcome resistance and improve personalized cancer treatments.

This study developed a novel regenerative platform using nanozyme-enabled materials combined with exosomes and laser stimulation to enhance wound healing in a mouse model, which more effectively regulated reactive oxygen species and improved early angiogenesis and collagen organization compared to conventional methods.

This study highlights that hydrogel formulations unexpectedly prolonged healing in trials, pointing to a need for design based on detailed pathophysiological insights rather than empirical methods, and suggests technologies like AI materials optimization and 3D bioprinting to aid their clinical use for cancer survivors.

This study developed innovative silica/natural polysaccharide hybrid nanoparticles encapsulating plant-derived 5-alpha-reductase inhibitors, reporting effective controlled release at hair follicle pH and lower cytotoxicity, suggesting a promising delivery system for antiandrogenic treatments.

This review discusses recent advancements in the development and use of polymer-based nanohydrogels for topical drug delivery, noting their potential to enhance drug loading, release control, and skin penetration for treating dermatological conditions.

This review discusses the role of jasmonic acid and its conjugates in enhancing plant stress tolerance and balancing growth and defense mechanisms but provides no new experimental data.

This study found that using renin-angiotensin system-targeting antihypertensive agents or statins is associated with reduced serum HER2 levels, which may influence the risk of metabolic syndrome in women.

This review explores the complex role of the Innate Immune System in rheumatoid arthritis, highlighting gaps in understanding its functions and interactions with the Adaptive Immune System, offering insights into potential biomarkers and therapeutic strategies for this challenging autoimmune condition.

This review highlights cellulose-based materials' potential in skin disease treatments, emphasizing their smart, responsive design for various conditions, with insights into their roles in wound healing, infection prevention, and wearable monitoring.

This review discusses how urban air pollutants may influence the regulation of JAK3 signaling in alopecia areata and reports no new experimental results; the authors integrate existing data to map potential pathways and biomarkers.

This review highlights the potential of microneedles for immunotherapy, emphasizing their ability to enhance immune responses and reduce side effects through precise and stimuli-responsive delivery, especially in tumor treatment, while also noting the limitations and areas for improvement in current systems.

This study explores the design of responsive drug carriers based on the tumor microenvironment to improve targeting and reduce side effects in cancer treatment, using a model of delivering curcumin with a responsive polymer carrier and evaluating potential errors due to cancer cell heterogeneity.

This review discusses the strategies and potential of CRISPR delivery for gene therapy, highlighting the challenges and innovative use of stimuli-responsive nanocarriers, but reports no new experimental results.

In this study, researchers used two dermal papilla spheroid models to investigate hair cycle regression mechanisms and found that the vascular system enhances tissue physiology and gene modulation, while Retinol-based treatments can partially recover tissue degeneration observed over an extended culture period.

This study found that glutathione deficiency affects lateral root and root hair responses to indole butyric acid in plants, but not to indole acetic acid, indicating its role in auxin pathway regulation.

This study reports on a zinc-coordinated tri-enzyme nanogel system (Zn@nGSC) that mimics natural enzymatic processes to enhance enzymatic activity and cascade efficiency, showing potential in wound healing, hyperglycemia treatment, and antibacterial effects in a murine model of post-pancreatectomy.

In this study, around 1% of proteins in skin fibroblasts significantly changed in response to reductive stress, affecting collagens and MAPK signaling pathways.

This study developed two sensitive spectrophotometric methods to accurately determine finasteride in pure and tablet forms, demonstrating linear response and compliance with ICH guidelines.

This review focuses on recent advances in smart responsive polymer microneedles, which offer precise, on-demand drug delivery triggered by external or physiological stimuli, highlighting significant research implications for transdermal drug administration according to this source.

In this study, exposure to the drug finasteride in Silurana tropicalis significantly increased testosterone levels in liver and testis tissues and altered gene expression related to male reproduction and oxidative stress.

This study found that differences in cashmere fiber diameter in Tibetan cashmere goats are associated with variations in metabolic, hypoxic, and stress response-related proteins, offering insights for breeding strategies.

This source reports on advances in stimulus-responsive nanoparticle-based PROTACs (nano-PROTACs), which aim to overcome existing challenges like poor cell permeability and systemic off-target effects by enabling controlled protein degradation through endogenous or exogenous stimuli, potentially enhancing therapeutic efficacy and reducing toxicity.

This symposium discussed why regenerative capacity varies among species and diminishes with age, exploring how these insights could inform regenerative medicine approaches, without presenting new experimental results.

This review discusses how various nutrients, such as flavonoids, probiotics, and omega-3 fatty acids, may support brain health by targeting stress-related pathways, potentially offering protective effects against neurodegenerative and psychiatric disorders through their roles in oxidative stress reduction and neuroinflammation regulation.

This review discusses advances in CRISPR/Cas9 variants and nanoformulations for cancer treatment, noting challenges and prospects for clinical application, but reports no new research results.