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This review discusses recent advancements in scar reduction techniques, highlighting promising therapeutic targets and the role of Wnt/β-catenin signaling in promoting scarless wound healing, but reports no new clinical results.

This study suggests that rather than inhibiting IL-15, selectively stimulating IL-15Ra-mediated signaling could be beneficial for managing alopecia areata and possibly other inflammatory hair loss conditions, as IL-15 promoted hair growth and maintained immune privilege in human hair follicles.

In this study, recombinant type III collagen was found to promote fibroblast proliferation and migration, suggesting potential anti-aging and repairing effects, although it was only effective in significantly inhibiting IL-6, not TNF-α, secretion.

This study found that IL-25-mediated-IL-17RB signaling improved diabetic wound healing by enhancing angiogenesis, collagen deposition, and endothelial cell function, suggesting a potential therapeutic strategy for poorly healing diabetic wounds.

This study demonstrated that safflower seeds can be engineered to express oleosin-FGF10, which showed a dose-dependent effect on cellular proliferation, potentially facilitating scalable protein production.

In this study, subcutaneous recombinant human IL-12 showed a 43% partial response rate in early-stage mycosis fungoides patients refractory to previous treatments, with generally mild to moderate adverse events reported.

In this study, iNKT10 cells were found to play a significant role in preventing and treating alopecia areata in a humanized mouse model, suggesting these cells could have potential in managing related autoimmune disorders.

This study found that transplanting hair follicles into human scars may remodel fibrotic tissue and reduce scarring by altering collagen structure and decreasing pro-fibrotic factors.

This study found that human γδTregs promoted hair regrowth and restored hair follicle immune privilege in a model of alopecia areata, suggesting potential for cell-based therapy in autoimmune diseases.

This study found that 17β-estradiol inhibited RANTES production in human keratinocytes by suppressing nuclear factor κB activity, suggesting a potential mechanism for 17β-estradiol's modulation of psoriasis-related inflammation.

This study reported that recombinant sonic hedgehog proteins can promote hair growth by activating hair-related genes and signaling pathways, suggesting potential as a therapeutic agent in mice.

This article reviews adverse skin reactions caused by chemotherapy and cytokine treatments, describing specific and nonspecific reactions, but reports no new clinical findings.

In this study, O. forskahlii seed oil was found to promote hair growth in rats and exhibit anti-aging effects on human skin cells by enhancing fibroblast proliferation and inhibiting inflammation and enzyme activity, indicating potential for cosmetic use.

This review discusses the biological and cosmetic aspects of hair aging and reports no new clinical results; it highlights current treatments and future research directions to address both aging factors.

This review discusses the therapeutic potential and safety of bioidentical recombinant human epidermal growth factor (rhEGF) for various skin and mucosa conditions and reports no new clinical results.

In this animal study, rats treated with recombinant human growth hormone (at both low and high doses) experienced quicker burn wound healing than controls, with increased micro vessel density and altered expression of vascular endothelial growth factor, alongside changes in oxidative stress and inflammation markers.

This study found that recombinant murine IL-36α increased the number of regenerated hair follicles and accelerated wound healing in a mouse model of wound-induced hair follicle neogenesis.

In this study, an immortalized MSC line from human adipose tissue showed potential for applications in regenerative medicine and inflammatory diseases through production of active factors, demonstrated in vitro.

This study found that Annexin A5 significantly reduced fibrosis and inflammation in both preventive and therapeutic contexts in a bleomycin-induced localized scleroderma mouse model, demonstrating its potential anti-fibrotic and anti-inflammatory effects for treating fibrotic diseases.

In this study, local injection of nanosized recombinant human erythropoietin at the injury site improved skin regeneration and re-epithelialization in a mouse model of deep second-degree burns through coexpression of specific receptors.

This study found that individuals with alopecia areata had significantly higher serum levels of retinol-binding protein 4 and increased IgG immunoreactivity against it, suggesting a role in the disease's pathogenesis.

IL-6 contributes to hair loss by shortening the growth phase and causing hair follicles to regress.

This study suggests that low-dose IL-2 and IL-15 may help restore immune tolerance in alopecia areata by maintaining Treg cell function, presenting a potential new treatment strategy.

This study found that Acanthus ebracteatus extract and verbascoside induced dermal papilla cell proliferation and reduced inflammatory cytokine release in vitro, suggesting potential for anti-hair loss applications.

This study found that recombinant human HGF/SF injections altered hair follicle growth cycles and mildly promoted hair elongation in mice, depending on their hair cycle stage.

This study found that human embryonic stem cell-derived mesenchymal stem cells promote hair growth and enhance the transition from the telogen phase to the anagen phase in mice, especially under hypoxic conditions.

This study suggests that IL-33 promotes hair follicle changes and T cell infiltration in psoriatic mice and humans, contributing to psoriatic alopecia.

This study suggests that finasteride's effect on promoting hair growth in men with androgenetic alopecia may be due to its inhibition of 5aR2 localized in hair follicles.

This study highlights that while hair follicle cycling is primarily influenced by growth factors like IGF-1 and Wnt signals, the role of cytokines in normal human hair growth and cycling is less understood.

This study found that local injections of interleukin-4 and neutralizing anti-interferon-γ antibody effectively treated alopecia in a mouse model, suggesting potential therapeutic pathways for human alopecia areata.