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A 15-year-old boy's severe scalp condition improved significantly with adalimumab and baricitinib treatment.

JAK inhibitors, like baricitinib, are effective and safe for treating alopecia areata.

The developed model can predict effective 5-alpha-reductase enzyme inhibitors.

Brepocitinib 30mg is most effective for moderate-to-severe alopecia areata, but ritlecitinib 50mg may offer a better balance of safety and effectiveness.

Machine learning can predict how well patients with alopecia areata will respond to certain treatments.

HDAC inhibitors, like Vorinostat and Entinostat, can help regrow hair in alopecia areata.

Cyclosporin A and FK506 can start new hair growth in mice, but ascomycin and rapamycin cannot.

Some patients taking finasteride or dutasteride may have ongoing sexual problems and depression even after stopping the medication.

MK-0773 safely increased muscle mass but did not improve muscle strength or function in elderly women with sarcopenia.

Antiandrogens like flutamide are effective in treating conditions like prostate cancer and hair loss, but there's a need for more potent versions. Understanding their structure can help develop better treatments.

The document concludes that adenosine receptor agonists have potential for treating various conditions, but only a few are approved due to challenges like side effects and the need for selective activation.

Targeting androgen receptors could be a promising way to treat skin disorders with fewer side effects.

Activating TRPV3 stops human hair growth.

Male hormones and their receptors play a key role in hair loss and skin health, with potential new treatments being explored.

A new mutation in the human glucocorticoid receptor reduces its function and causes resistance to glucocorticoids.

5α-reductase inhibitors can cause sexual problems, higher risk of aggressive prostate cancer, and depression.

Genetic differences may affect COVID-19 deaths; anti-androgens could be potential treatment.

The document concludes that targeting the androgen receptor may be a promising breast cancer treatment, especially for certain types.

Overexpressing the mineralocorticoid receptor in mouse skin causes skin thinning, early skin barrier development, eye issues, and hair loss.

Finasteride and dutasteride effectively treat hair loss, but may cause side effects like sexual dysfunction and depression.

Both drugs lower DHT levels, with GI198745 being more effective.

5α-reductase inhibitors increase the risk of sexual dysfunction, especially in men with enlarged prostate.

Antidepressants, 5α-reductase inhibitors, and isotretinoin can cause long-lasting sexual dysfunction.

The length of the CAG repeat in the androgen receptor gene affects the risk and progression of prostate cancer, BPH, infertility, and undermasculinized genitalia.

Using finasteride or dutasteride may cause long-lasting erectile dysfunction.

Four new compounds were more effective than finasteride in treating prostate issues and hair loss, with one being 100 times more active and safe for use.

The mineralocorticoid receptor may play a role in skin and hair health and could be a new target for treating related disorders.

5-alpha-reductase inhibitors may reduce COVID-19 symptoms in bald males.

Chitosan-coated nanoparticles improve skin delivery of hair loss treatments with fewer side effects.

Certain leukemia drugs can cause severe skin reactions that may require stopping treatment.