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Retinoids increase steroid sulfatase activity in leukemia cells through RARα/RXR and involves certain pathways like phosphoinositide 3-kinase and ERK-MAP kinase.

Melasma's causes include genetics, sun exposure, hormones, and oxidative stress, and understanding these can help create better treatments.

Environmental factors at different levels control hair stem cell activity, which could lead to new hair growth and alopecia treatments.

Some medicinal plants can help heal wounds and may lead to new treatments.

Stem cell plasticity is crucial for wound healing but can also contribute to cancer development.

Blocking the Wnt pathway could lead to new treatments for cancer and tissue repair but requires careful development to avoid side effects.

Stem cells help remove dead cells to keep tissues healthy by balancing cell replacement and clearance.

Decursin shows promise for treating cancer, neuroprotection, inflammation, and hair loss.

NcoA4 may have roles beyond helping control gene activity, possibly affecting cell behavior and stability.

New findings explain how genetic changes, body clocks, and certain molecules affect tissue response to stress hormones.

DHT affects bone growth by altering gene activity in osteoblasts, potentially complicating steroid use.

The Wnt signaling pathway is not a major factor in the development of keratoacanthoma, a type of skin tumor.

miR-29 is a key factor that accelerates aging.

The mineralocorticoid receptor may play a role in skin and hair health and could be a new target for treating related disorders.

Tcf3 helps cells move and heal wounds by controlling lipocalin 2.

Activating TLR5 in the gut can extend lifespan and improve health in aged mice.

Indian Hedgehog helps control skin cell growth and protects against aggressive skin cancer.

Baricitinib reduces inflammation and improves cell health in premature aging cells.

Vitamin D receptor helps control hair growth and could be used to treat certain skin tumors.

Testosterone may slow down wound healing and increase inflammation.

Some heart drugs show promise for other conditions, but more research is needed to confirm their effectiveness and safety.

MED1 affects skin wound healing differently in young and old mice.

Cholesterol sulfate buildup due to a genetic mutation disrupts the skin barrier, leading to the scaling skin seen in X-linked ichthyosis.

Natural 5α-reduced glucocorticoids might be anti-inflammatory with fewer side effects than current options.

The Brazilian Society of Dermatology agrees that oral isotretinoin is effective for acne and other skin conditions, and it's safe when monitored, but more research is needed on dosing and duration.

Hair growth environment recreated with challenges; stem cells make successful skin organoids.

Cell death shapes skin stem cell environments, affecting inflammation, repair, and cancer.

PPAR agonists show promise for skin conditions but need more research before being a main treatment.

Skin abnormalities can indicate immunodeficiency due to shared origins with the immune system.

Blocking COX, especially COX-2, in the skin can reduce inflammation and pain and may help prevent skin cancer.