This study of patients with moderate to severe alopecia areata in Morocco found that oral betamethasone mini-pulses yielded ≥50% hair regrowth in 62.5% of cases, improved quality of life scores, and were generally well-tolerated, though relapses and mild side effects were noted.
1 citations
,
September 2023 in “Journal of the American Academy of Dermatology” Mini pulse corticosteroid therapy with oral dexamethasone is effective and has fewer side effects for treating extensive alopecia areata.
18 citations
,
August 2011 in “Clinical Drug Investigation” This study found that a combination of low-dose isotretinoin and oral azithromycin pulse effectively treats severe acne with an acceptable side effect profile and relatively low relapse rates.
10 citations
,
July 2019 in “Indian Journal of Dermatology” This study found that azathioprine pulse therapy and betamethasone both effectively managed alopecia areata with similar hair regrowth results, though betamethasone had significantly more side effects, suggesting azathioprine as a preferable alternative to corticosteroids.
April 2025 in “Pakistan Journal of Health Sciences” This study demonstrated that weekly azathioprine pulse therapy was more effective than betamethasone oral mini-pulse in promoting hair regrowth in patients with moderate to severe alopecia areata.
May 2015 in “Journal of The American Academy of Dermatology” Both treatments help with hair regrowth in alopecia areata, but azathioprine has milder side effects than betamethasone.
March 2022 in “Nepal Journal of Dermatology Venereology & Leprology” In this prospective clinical trial, azathioprine with steroid minipulse therapy and methotrexate with steroid minipulse therapy both improved hair regrowth in alopecia areata patients, but methotrexate showed slightly higher efficacy.
April 2019 in “Journal of Investigative Dermatology” This study reported that gain-of-function mutations in TRPV3 lead to hair loss in mice by disrupting inner root sheath keratinocyte differentiation, ultimately causing follicular keratinocyte stem cell exhaustion and permanent follicle disruption.
2 citations
,
December 2024 in “Journal of Photochemistry and Photobiology B Biology” This study suggests that pulsed wave photobiomodulation could be a promising treatment for androgenetic alopecia by enhancing dermal papilla cell function through specific light parameters, particularly frequency.
2 citations
,
March 2019 in “Lasers in surgery and medicine” This study found that human hair follicles demonstrated a dose-dependent response to light in an ex vivo photoepilation model, which could predict the clinical efficacy and permanency of light-based hair removal devices.
January 2023 in “The Egyptian Journal of Hospital Medicine ” This review suggests that fractional CO2 laser treatment may be a promising option for treating alopecia areata with a good safety profile.
February 2020 in “Journal of Physics Conference Series” This study found that laser hair removal is optimal for light to moderate skin tones using 10-15 J/cm² at 755 nm and for dark skin with 4.5-10 J/cm² at 755-1064 nm.
3 citations
,
September 2015 in “Plastic and reconstructive surgery/PSEF CD journals” Low-dose pulsed electric fields in a rat model shifted hair follicles from resting to active growth, with voltage as the most influential factor.
October 2025 in “Journal of Cosmetic Dermatology” This study found that the AOPT-MTL mode is an effective and safe treatment option for nasal blackheads in Asians, indicating potential for widespread clinical use.
51 citations
,
October 2002 in “Archives of dermatology” This case study of a patient with dissecting cellulitis of the scalp found that multiple medications, including isotretinoin, achieved only modest improvement, and symptoms returned after treatments were stopped.
July 2025 in “Clinical Medicine” In this institution-based randomized trial, oral betamethasone mini-pulse therapy for alopecia areata showed a faster therapeutic response compared to oral tofacitinib, as measured by trichoscopic changes and achievement of 50% hair regrowth.
24 citations
,
March 2015 in “Dermatologic Surgery” This review discusses the modest efficacy of home-use laser and light devices for conditions like hair removal and acne, noting limited evidence and a lack of robust trials.
This article reviews traditional and modern methods for treating pilosis with both Korean medicine and current technologies, but it does not provide new clinical results.
3 citations
,
January 2017 in “Stem Cells International” This article highlights the significant challenge that tissue regeneration presents to modern medicine, emphasizing its importance in improving quality of life.
May 2002 in “Therapeutische Umschau” This article reviews existing treatments for hypertrichosis and hirsutism, noting that while eflornithine is a promising new option, the efficacy of systemic antiandrogens remains unproven in modern clinical studies.
6 citations
,
April 2000 in “European journal of plastic surgery” This study found that repeated treatments with the long-pulsed ruby laser result in a small but statistically significant reduction in unwanted hair, with high patient satisfaction despite modest efficacy.
1 citations
,
August 2012 in “Journal of acupuncture and meridian studies” This review discusses the diagnostic classification and traditional Korean medicine treatments for abnormal hair growth and reports no new clinical results; it suggests that combining these with modern technology may enhance cosmetology advances.
November 2022 in “Pakistan Armed Forces Medical Journal” This study found that intense pulse light and diode laser treatments were similarly effective and tolerable for reducing unwanted facial hair in female patients with hirsutism, with no significant differences in hair reduction, adverse effects, or patient satisfaction between the two methods.
January 2006 in “Zhongguo linchuang jiepouxue zazhi” This study found that applying a low intensive pulse magnetic field significantly accelerated wound healing in rats by promoting the proliferation and differentiation of skin epidermal stem cells.
112 citations
,
July 1998 in “Journal of Investigative Dermatology” This study found that anagen-phase hair follicles in mice are particularly sensitive to damage by ruby laser pulses, resulting in alopecia without scarring, suggesting enhanced laser hair removal strategies.
15 citations
,
May 2017 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology” This article is a letter to the editor about high-dose pulsed corticosteroid therapy combined with methotrexate for severe childhood alopecia areata and provides no new clinical results.
5 citations
,
July 2016 in “Journal of Clinical Hypertension” This study found that hypertensive patients with severe androgenic alopecia exhibited impaired coronary microcirculation, suggesting they may face increased cardiovascular risk.
150 citations
,
April 1999 in “Dermatologic Clinics” This article reviews the biological and physical principles of laser hair removal and reports that current laser systems do not consistently achieve permanent hair follicle destruction across treated areas.
1 citations
,
August 1984 in “Therapeutische Umschau. Revue thérapeutique” This article reviews treatments for facial hypertrichosis and hirsutism and reports no new clinical findings; the authors highlight the potential of laser and pulsed flash-light systems for permanent hair removal.
31 citations
,
February 1999 in “Dermatologic surgery” This report describes a case where solar-induced postinflammatory hyperpigmentation following laser hair removal was treated with a combination of topical treatments and serial TCA peels, resulting in only slight improvement.