Efficacy and Safety of Oral Betamethasone Mini-Pulses in Moderate to Severe Alopecia Areata

    May 2025 in “ Cureus ”
    Rasha Moumna, Zineb Loubaris, A. Mountassir … Mariame Meziane
    Studysummary This study of patients with moderate to severe alopecia areata in Morocco found that oral betamethasone mini-pulses yielded ≥50% hair regrowth in 62.5% of cases, improved quality of life scores, and were generally well-tolerated, though relapses and mild side effects were noted.
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    Research cited in this study 12

    1. Alopecia Areata: Understanding the Pathophysiology and Advancements in Treatment Modalities Cureus · 2025
    2. Update on Pulse Corticosteroid Therapy for the Management of Alopecia Areata JEADV Clinical Practice · 2024
    3. European Expert Consensus Statement on the Systemic Treatment of Alopecia Areata JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology · 2024
    4. Efficacy and Adverse Effects of Corticosteroid Pulse Therapy in Alopecia Areata Dermatology practical & conceptual · 2023
    5. Hair Loss Profiles and Ritlecitinib Efficacy in Patients with Alopecia Areata: Post Hoc Analysis of the Allegro Phase 2b/3 Study Dermatology and therapy · 2023
    6. Alopecia Areata and Dexamethasone Mini-Pulse Therapy: A Prospective Cohort Study on Real World Evidence and Factors Related to Successful Response Journal of Clinical Medicine · 2022
    7. Weekly Azathioprine Pulse Versus Betamethasone Oral Mini-Pulse in the Treatment of Moderate-to-Severe Alopecia Areata Indian Journal of Dermatology · 2019
    8. Chronological Clinicopathological Characterization of Rapidly Progressive Alopecia Areata Resistant to Multiple Intravenous Corticosteroid Pulse Therapies: An Implication for Improving Efficacy The Journal of Dermatology · 2018
    9. Pulse Corticosteroid Therapy With Oral Dexamethasone for the Treatment of Adult Alopecia Totalis and Universalis Journal of the American Academy of Dermatology · 2016
    10. Extensive Alopecia Areata: Not Necessarily Recalcitrant to Therapy International Journal of Trichology · 2011
    11. Extensive Alopecia Areata Treated With Betamethasone Oral Mini-Pulse Therapy: An Open Uncontrolled Study PubMed · 2007
    12. Placebo-Controlled Oral Pulse Prednisolone Therapy in Alopecia Areata Journal of the American Academy of Dermatology · 2005

    Related research 1

    1. Twenty Nail Dystrophy with Alopecia Areata in an Atopic Child International journal of research in dermatology · 2019