Chronological Clinicopathological Characterization of Rapidly Progressive Alopecia Areata Resistant to Multiple Intravenous Corticosteroid Pulse Therapies: An Implication for Improving Efficacy

    July 2018 in “ The Journal of Dermatology
    Masataka Fukuyama, Yohei Sato, Misaki Kinoshita‐Ise, Y. Yamazaki, Manabu Ohyama
    TLDR Current corticosteroid pulse therapy is not very effective for severe rapidly progressive alopecia areata.
    The study assessed the efficacy of repeated intravenous corticosteroid pulse therapy in eight patients with rapidly progressive alopecia areata (RP-AA) who did not respond to initial treatment. Despite additional rounds of pulse therapy, which involved administering methylprednisolone, only three patients showed partial hair regrowth, and all eventually relapsed. Histopathological analysis revealed persistent and severe perifollicular lymphocytic inflammation in these patients, suggesting that the current repetitive pulse therapy is limited in effectiveness for RP-AA cases with extensive inflammation. The study concluded that modifying the dose and interval of pulse therapy, along with alternative treatments, might be necessary for better outcomes.
    Discuss this study in the Community →

    Cited in this study

    17 / 17 results

    Related

    3 / 3 results