3 citations
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September 2021 in “International Journal of Molecular Sciences” This study suggests that women with polycystic ovary syndrome may have an increased risk of COVID-19-related cardiac and renal complications, and that weight loss through lifestyle changes could help reduce these risks.
3 citations
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April 1997 in “Developmental Dynamics” In this study, topical trypsin treatment following depilation in a mouse model induced cell death at the follicular papilla, delaying hair growth and pigmentation.
2 citations
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September 2022 in “Composites Part B: Engineering” This study found that multifunctional peptide-based materials derived from Crassostrea gigas may promote scarless dermal wound healing without affecting intestinal flora through both topical and oral administration.
1 citations
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February 2013 in “InTech eBooks” This article discusses research about Netherton syndrome, highlighting its contributions to understanding epidermal structure, immune responses, and processes like atopic dermatitis, but it reports no new clinical findings.
1 citations
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April 1998 in “PubMed” This study suggested that Nexin 1, a powerful serine-protease inhibitor, may have a role in regulating hair follicle growth by influencing cellular growth and differentiation.
February 2026 in “Human Cell” This study found that factors released by mesenchymal stromal cells can enhance the proliferation and migration of keratinocytes in vitro, which may contribute to improved understanding of their role in wound healing and potential applications in dermal regeneration therapies.
July 2025 in “Journal of Investigative Dermatology” TRIV-509 quickly improves skin barrier and cell health in atopic dermatitis.
November 2019 in “Harper's Textbook of Pediatric Dermatology” This article reviews Netherton syndrome, focusing on its genetic basis, clinical presentation, and treatment options, and reports no clinical results; the authors mention potential benefits of targeted therapies and gene therapy.
August 2019 in “Journal of The American Academy of Dermatology” This study found that bleach baths using 0.005% hypochlorite directly affected serine protease expression in skin cells and reduced skin pH in patients with atopic dermatitis, suggesting potential therapeutic benefits.
May 2017 in “Journal of The American Academy of Dermatology” PLAU and SerpinB2 affect cell death differently in various forms of leprosy and could be targets for new treatments.
April 2017 in “IOSR journal of dental and medical sciences” This abstract discusses Netherton Syndrome, a genetic disorder with a characteristic triad of symptoms caused by SPINK5 gene mutation, and reports no new clinical findings or treatment advances.
January 2012 in “한국미용학회지” This study found that gene expression changes in hair bulb cells are linked to graying hair, affecting processes like melanogenesis and cell-cell interaction.
137 citations
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October 2009 in “The American journal of pathology” This study found that matriptase, a membrane serine protease, is crucial for maintaining multiple types of epithelial tissues in mice, with its absence leading to severe organ dysfunction and increased permeability.
8 citations
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January 2017 in “Journal of Biological Chemistry” This study found that astrotactin-2 undergoes unique intramembrane proteolysis during maturation, revealing specific transmembrane topologies and substrate sequence requirements for cleavage.
1 citations
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January 2008 in “Massey Research Online (Massey University)” This study found that enzyme depilation of lambskins can cause damage due to the removal of collagen VI, suggesting the need for a protease that avoids this interaction for successful application.
December 2023 in “American journal of medical genetics. Part A” In this study, researchers identified compound heterozygous variants in the MBTPS1 gene associated with ectodermal dysplasia features in a 14-year-old female, broadening the known disorder spectrum linked to these genetic mutations.
April 2022 in “Brazilian Medical Students” This review synthesizes existing evidence on the link between androgenic alopecia and severe COVID-19 outcomes, noting a potential role for anti-androgenic therapies in treating SARS-CoV-2 infections.
January 2022 in “International Journal of Science and Research (IJSR)” This review discusses the biochemical and psychological impacts of polycystic ovary syndrome on immune functions against COVID-19 but reports no new clinical results.
September 2021 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that enteroendocrine cells play a key role in coordinating stem cell migration towards wounds in the Drosophila intestinal epithelium, aiding tissue repair through non-canonical Wnt signaling.
September 2017 in “Journal of Investigative Dermatology” This study found that hyaluronic acid increased the size and cell proliferation of mixed aggregates in a 3D culture model, indicating its role in human hair follicle germ-like structure formation without enhancing dermal papilla cell markers.
April 2012 in “Cancer Research” In this study, mouse models with EGFR deficiency showed that disrupted hair follicle cycling leads to increased mast cell numbers and inflammation, suggesting EGFR's role in managing hair cycle transitions and preventing folliculitis.
September 2011 in “Urology” This study reports on biofeedback treatment for dysfunctional voiding in three adult cases, providing insights into this condition when diagnosed beyond childhood.
May 2026 in “Bioactive Materials” This study reported that in degenerative alopecia, Zn²⁺/Cu²⁺-dependent proteases are downregulated and destabilized, and a specially developed microneedle patch reactivated these enzymes, reduced senescence, and enhanced hair regeneration in an animal model.
August 2019 in “Journal of The American Academy of Dermatology” This study found that a bleach bath treatment with 0.005% HOCI reduced the expression of certain serine proteases in cultured keratinocytes and lowered skin pH in atopic dermatitis patients, potentially improving symptoms by modulating the NF-kB pathway.
5 citations
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January 2009 in “Dermato-endocrinology” This study suggests that ADAM 10 and 12 proteases may play important roles in the regulation of hair cycling through their expression patterns in hair follicle structures.
This article responds to "The Assessment and Treatment of Geezers" by highlighting that some individuals protest against perceived self-importance and verbosity despite fitting the geezer definition.
15 citations
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April 2011 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that A(3)B(5) downregulates melanin production and suppresses melanoma cell growth by promoting proteasomal degradation of TRP-2.
May 2010 in “Europe PMC (PubMed Central)” This chapter discusses the synthesis and analysis of near-infrared fluorescent activity-based probes for imaging cysteine protease activity, reporting potential benefits for disease diagnosis but noting challenges in imaging specific locations with high cathepsin activity.
7 citations
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June 2007 in “AIDS” This report describes the first case of hair loss in a patient on ritonavir-boosted atazanavir therapy for HIV, with hair regrowth following a switch to a non-protease inhibitor regimen.
6 citations
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January 2021 in “Journal of the mechanics and physics of solids/Journal of the Mechanics and Physics of Solids” This study's simulations suggest that biomechanical factors, like follicle geometry and tissue stiffness, are likely significant in hair fiber protrusion, providing a framework for future experimental validation.